School of Medicine, Chapel Hill, University of North Carolina at Chapel Hill, North Carolina.
Corresponding author: Alex K. Gertner, MD, PhD, 321 S Columbia St, Chapel Hill, NC 27516 (
J Clin Psychiatry. 2023 Apr 5;84(3):22m14496. doi: 10.4088/JCP.22m14496.
People with serious mental illness (SMI) have high rates of cardiometabolic illness, receive low quality care, and experience poor outcomes. Nevertheless, studies of existing integrated care models have not consistently shown improvements in cardiometabolic health for people with SMI. This study assessed the effect of a novel model of enhanced primary care for people with SMI on cardiometabolic outcomes. Enhanced primary care is a model of integrated care wherein comprehensive primary care delivery is adapted to the needs of people with SMI in coordination with behavioral care. We conducted a propensity-weighted cohort study comparing 234 patients with SMI receiving enhanced primary care to 4,934 patients with SMI receiving usual primary care using electronic health data from a large academic medical system covering the years 2014-2018. The propensity-weighted models controlled for baseline differences in outcome measures and patient characteristics between groups. Compared to usual primary care, enhanced primary care increased hemoglobin A (HbA) screening by 18 percentage points (95% confidence interval [CI], 10 to 25), low-density lipoprotein (LDL) screening by 16 percentage points (CI, 8.8 to 24), and blood pressure screening by 7.8 percentage points (CI, 5.8 to 9.9). Enhanced primary care reduced HbA by 0.27 percentage points (CI, -0.47 to -0.060) and systolic blood pressure by 3.9 mm Hg (CI, -5.2 to -2.5) compared to usual primary care. We did not find evidence that enhanced primary care consistently affected glucose screening, LDL values, or diastolic blood pressure. Enhanced primary care can achieve clinically meaningful improvements in cardiometabolic health compared to usual primary care.
患有严重精神疾病 (SMI) 的人患心血管代谢疾病的比率较高,接受的护理质量较差,且预后较差。尽管如此,对现有综合护理模式的研究并未一致显示出 SMI 患者心血管代谢健康状况的改善。本研究评估了一种新型强化初级保健模式对 SMI 患者心血管代谢结果的影响。强化初级保健是一种综合护理模式,其中全面的初级保健服务根据 SMI 患者的需求进行调整,并与行为护理相协调。我们进行了一项倾向评分加权队列研究,比较了接受强化初级保健的 234 名 SMI 患者和接受常规初级保健的 4934 名 SMI 患者的心血管代谢结果,使用了来自一个大型学术医疗系统的电子健康数据,该系统涵盖了 2014-2018 年的年份。倾向评分加权模型控制了组间基线结果测量和患者特征的差异。与常规初级保健相比,强化初级保健使血红蛋白 A(HbA)筛查增加了 18 个百分点(95%置信区间 [CI],10 至 25),低密度脂蛋白(LDL)筛查增加了 16 个百分点(CI,8.8 至 24),血压筛查增加了 7.8 个百分点(CI,5.8 至 9.9)。与常规初级保健相比,强化初级保健使 HbA 降低了 0.27 个百分点(95%CI,-0.47 至 -0.060),收缩压降低了 3.9mmHg(95%CI,-5.2 至 -2.5)。我们没有发现强化初级保健对葡萄糖筛查、LDL 值或舒张压有一致影响的证据。与常规初级保健相比,强化初级保健可以在心血管代谢健康方面取得有临床意义的改善。