Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea.
Department of Veterinary Imaging, Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University Cheongju, Chungbuk, South Korea.
Am J Vet Res. 2023 Apr 10;84(6). doi: 10.2460/ajvr.23.01.0012. Print 2023 Jun 1.
To investigate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in dogs with myxomatous mitral valve disease (MMVD).
106 dogs with MMVD and 22 healthy dogs were included in the study.
CBC data were obtained retrospectively, and NLR, MLR, and PLR were compared between dogs with MMVD and healthy dogs. The ratios were also analyzed according to MMVD severity.
NLR and MLR were significantly higher in dogs with MMVD C and D (NLR of 4.99 [3.69-7.27]; MLR of 0.56 [0.36-0.74]) than in healthy dogs (NLR: 3.05 [1.82-3.37], P < .001; MLR: 0.21 [0.14-0.32], P < .001), MMVD stage B1 (NLR: 3.15 [2.15-3.86], P < .001; MLR: 0.26 [0.20-0.36], P < .001), and MMVD stage B2 dogs (NLR: 3.22 [2.45-3.85], P < .001; MLR: 0.30 [0.19-0.37], P < .001). The area under the receiver operating characteristic curves of the NLR and MLR to distinguish dogs with MMVD C and D from those with MMVD B were 0.84 and 0.89, respectively. The optimal cutoff value for NLR was 4.296 (sensitivity, 68%; specificity, 83.95%), and the MLR value was 0.322 (sensitivity, 96%; specificity, 66.67%). NLR and MLR were significantly decreased after treatment in dogs with congestive heart failure (CHF).
NLR and MLR can be used as adjunctive indicators of CHF in dogs.
研究中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）和血小板与淋巴细胞比值（PLR）在患有黏液样心肌二尖瓣病（MMVD）的犬中的变化。
本研究纳入了 106 只 MMVD 犬和 22 只健康犬。
回顾性获取全血细胞计数数据，并比较 MMVD 犬和健康犬之间的 NLR、MLR 和 PLR。还根据 MMVD 严重程度对比值进行了分析。
MMVD C 和 D 级犬的 NLR 和 MLR 显著高于健康犬（NLR：4.99[3.69-7.27]；MLR：0.56[0.36-0.74]，P<0.001；NLR：3.05[1.82-3.37]，P<0.001）、MMVD 阶段 B1 犬（NLR：3.15[2.15-3.86]，P<0.001；MLR：0.26[0.20-0.36]，P<0.001）和 MMVD 阶段 B2 犬（NLR：3.22[2.45-3.85]，P<0.001；MLR：0.30[0.19-0.37]，P<0.001）。NLR 和 MLR 区分 MMVD C 和 D 级犬与 MMVD B 级犬的受试者工作特征曲线下面积分别为 0.84 和 0.89。NLR 的最佳截断值为 4.296（敏感性，68%；特异性，83.95%），MLR 值为 0.322（敏感性，96%；特异性，66.67%）。充血性心力衰竭（CHF）犬治疗后 NLR 和 MLR 显著降低。
NLR 和 MLR 可作为犬 CHF 的辅助指标。
