College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Inflamm Res. 2023 May;72(5):1037-1050. doi: 10.1007/s00011-023-01729-9. Epub 2023 Apr 6.
Metabolic reprogramming is one of the important mechanisms of cell differentiation, and different cells have different preferences for energy sources. During the differentiation of naive CD4 + T cells into Th17 and Treg cells, these cells show specific energy metabolism characteristics. Th17 cells depend on enhanced glycolysis, fatty acid synthesis, and glutaminolysis. In contrast, Treg cells are dependent on oxidative phosphorylation, fatty acid oxidation, and amino acid depletion. As a potent antimalarial drug, artesunate has been shown to modulate the Th17/Treg imbalance and regulate cell metabolism.
Relevant literatures on ART, cellular metabolism, glycolysis, lipid metabolism, amino acid metabolism, CD4 + T cells, Th17 cells, and Treg cells published from January 1, 2010 to now were searched in PubMed database.
In this review, we will highlight recent advances in which artesunate can restore the Th17/Treg imbalance in disease states by altering T-cell metabolism to influence differentiation and lineage selection. Data from the current study show that few studies have focused on the effect of ART on cellular metabolism. ART can affect the metabolic characteristics of T cells (glycolysis, lipid metabolism, and amino acid metabolism) and interfere with their differentiation lineage, thereby regulating the balance of Th17/Treg and alleviating the symptoms of the disease.
代谢重编程是细胞分化的重要机制之一，不同的细胞对能源有不同的偏好。在初始 CD4+T 细胞向 Th17 和 Treg 细胞分化的过程中，这些细胞表现出特定的能量代谢特征。Th17 细胞依赖于增强的糖酵解、脂肪酸合成和谷氨酰胺分解。相比之下，Treg 细胞依赖于氧化磷酸化、脂肪酸氧化和氨基酸耗竭。青蒿琥酯作为一种有效的抗疟药物，已被证明能调节 Th17/Treg 失衡并调节细胞代谢。
在 PubMed 数据库中检索了 2010 年 1 月 1 日至现在发表的关于 ART、细胞代谢、糖酵解、脂质代谢、氨基酸代谢、CD4+T 细胞、Th17 细胞和 Treg 细胞的相关文献。
在这篇综述中，我们将强调青蒿琥酯通过改变 T 细胞代谢来影响分化和谱系选择，从而恢复疾病状态下 Th17/Treg 失衡的最新进展。目前的研究数据表明，很少有研究关注 ART 对细胞代谢的影响。ART 可以影响 T 细胞的代谢特征（糖酵解、脂质代谢和氨基酸代谢），并干扰它们的分化谱系，从而调节 Th17/Treg 的平衡，缓解疾病症状。
