Du Dan, He Jing, Ju Chenxi, Wang Chang, Li Hongle, He Fucheng, Zhou Mingxia
Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Cancer Lett. 2023 May 28;562:216165. doi: 10.1016/j.canlet.2023.216165. Epub 2023 Apr 5.
N-methylguanosine (mG) methylation, one of the most common RNA modifications in eukaryotes, has recently gained considerable attention. The biological functions of mG modification in RNAs, including tRNA, rRNA, mRNA, and miRNA, remain largely unknown in human diseases. Owing to rapid advances in high-throughput technologies, increasing evidence suggests that mG modification plays a critical role in cancer initiation and progression. As mG modification and hallmarks of cancer are inextricably linked together, targeting mG regulators may provide new possibilities for future cancer diagnoses and potential intervention targets. This review summarizes various detection methods for mG modification, recent advances in mG modification and tumor biology regarding their interplay and regulatory mechanisms. We conclude with an outlook on the future of diagnosing and treating mG-related diseases.
N-甲基鸟苷（mG）甲基化是真核生物中最常见的RNA修饰之一，最近受到了广泛关注。mG修饰在包括tRNA、rRNA、mRNA和miRNA在内的RNA中的生物学功能在人类疾病中仍 largely未知。由于高通量技术的迅速发展，越来越多的证据表明mG修饰在癌症的发生和发展中起关键作用。由于mG修饰与癌症的特征密切相关，靶向mG调节剂可能为未来的癌症诊断和潜在干预靶点提供新的可能性。本综述总结了mG修饰的各种检测方法，以及mG修饰与肿瘤生物学在其相互作用和调控机制方面的最新进展。我们最后展望了诊断和治疗与mG相关疾病的未来。
