METTL1/WDR4和QKI作为m7G修饰相关酶在消化系统疾病中的作用。
Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases.
作者信息
Zhou Wenyan, Yi Yan, Cao Wenyu, Zhong Xiaolin, Chen Ling
机构信息
Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Institute Center of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
出版信息
Front Pharmacol. 2025 Jan 9;15:1491763. doi: 10.3389/fphar.2024.1491763. eCollection 2024.
N-methylguanosine (m7G) modification is one of the most prevalent forms of chemical modification in RNA molecules, which plays an important role in biological processes such as RNA stability, translation regulation and ribosome recognition. Methyl-transferation of m7G modification is catalyzed by the enzyme complex of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4), and Quaking (QKI) recognizes internal m7G methylated mRNA and regulates mRNA translation and stabilization. Recent studies have found that m7G modification - related enzymes are associated with the onset and progression of digestive cancer, such as colorectal cancer, liver cancer, and other digestive diseases such as ulcerative colitis. This review will focus on the latest research progress on the roles of m7G methyltransferase METTL1/WDR4 and recognized enzyme QKI in digestive diseases.
N-甲基鸟苷（m7G）修饰是RNA分子中最普遍的化学修饰形式之一，在RNA稳定性、翻译调控和核糖体识别等生物学过程中发挥着重要作用。m7G修饰的甲基化转移由类甲基转移酶1（METTL1）和WD重复结构域4（WDR4）的酶复合物催化，而震颤蛋白（QKI）识别内部m7G甲基化的mRNA并调节mRNA的翻译和稳定性。最近的研究发现，m7G修饰相关酶与消化系统癌症（如结直肠癌、肝癌）的发生和发展以及其他消化系统疾病（如溃疡性结肠炎）有关。本综述将聚焦于m7G甲基转移酶METTL1/WDR4和识别酶QKI在消化系统疾病中作用的最新研究进展。
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