Lavrard-Meyer P, Gomes De Pinho Q, Daumas A, Benyamine A, Ebbo M, Schleinitz N, Harlé J R, Jarrot P A, Kaplanski G, Berbis J, Granel B
Assistance Publique des hôpitaux de Marseille (APHM), hôpital Nord, service de médecine interne, Aix-Marseille Université (AMU), Marseille, France.
Assistance Publique des hôpitaux de Marseille (APHM), hôpital Nord, service de médecine interne, Aix-Marseille Université (AMU), Marseille, France.
Rev Med Interne. 2023 May;44(5):212-217. doi: 10.1016/j.revmed.2023.02.002. Epub 2023 Apr 5.
Infections are associated with morbimortality of patients with giant cell arteritis (GCA). The aim of this work was twofold: the identification of factors predisposing to the risk of infection and the description of patients hospitalized with an infection occurring during the treatment period of CAG.
A monocentric retrospective study was conducted in GCA patients, comparing patients hospitalized for infection with patients without infection. The analysis included 21/144 (14.6%) patients with 26 infections (cases) and 42 control matched on sex, age, and diagnosis of GCA.
Both groups were similar except for a higher frequency of seritis in cases (15% vs. 0%, p=0.03). Relapses of GCA were less common in cases (23.8% vs 50.0%, p=0.041). Hypogammaglobulinemia was present during infection. More than half of the infections (53.8%) occurred in the first year of follow-up with an average dose of 15mg/day of corticosteroids. Infections were mainly pulmonary (46.2%) and cutaneous (26.9%).
Factors associated with infectious risk were identified. This preliminary monocentric work will continue with a national multicentre study.
感染与巨细胞动脉炎（GCA）患者的发病和死亡相关。本研究的目的有两个：确定易导致感染风险的因素，并描述在GCA治疗期间因感染住院的患者情况。
对GCA患者进行单中心回顾性研究，比较因感染住院的患者和未感染患者。分析纳入了21/144（14.6%）例发生26次感染的患者（病例组）以及42例在性别、年龄和GCA诊断方面匹配的对照组。
除病例组中浆膜炎的发生率较高（15%对0%，p=0.03）外，两组相似。GCA复发在病例组中不太常见（23.8%对50.0%，p=0.041）。感染期间存在低丙种球蛋白血症。超过一半的感染（53.8%）发生在随访的第一年，当时平均每天使用15毫克皮质类固醇。感染主要为肺部感染（46.2%）和皮肤感染（26.9%）。
确定了与感染风险相关的因素。这项初步的单中心研究将继续开展全国多中心研究。
