Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Qatar Foundation, Doha, Qatar.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.
J Physiol. 2024 Apr;602(8):1449-1462. doi: 10.1113/JP283826. Epub 2023 Apr 22.
Store operated Ca entry (SOCE) is a ubiquitous signalling module with established roles in the immune system, secretion and muscle development. Recent evidence supports a complex role for SOCE in the nervous system. In this review we present an update of the current knowledge on SOCE function in the brain with a focus on its role as a regulator of brain activity and excitability.
钙库操作钙内流(SOCE)是一种普遍存在的信号模块,在免疫系统、分泌和肌肉发育中具有既定的作用。最近的证据支持 SOCE 在神经系统中具有复杂的作用。在这篇综述中,我们介绍了目前关于 SOCE 在大脑中的功能的最新知识,重点介绍了它作为大脑活动和兴奋性调节剂的作用。