Department of Gynaecology, Royal Hospital for Women, New South Wales, Sydney, Australia.
Department of Gynaecology, University of New South Wales, New South Wales, Sydney, Australia.
Aust N Z J Obstet Gynaecol. 2023 Jun;63(3):418-424. doi: 10.1111/ajo.13678. Epub 2023 Apr 8.
The aim is to report the results of Australia's first uterus transplantation (UTx).
Following long-standing collaboration between the Swedish and Australian teams, Human Research Ethics approval was obtained to perform six UTx procedures in a collaborative multi-site research study (Western Sydney Local District Health 2019/ETH13038), including Royal Hospital for Women, Prince of Wales Hospital, and Westmead Hospital in New Souh Wales. Surgeries were approved in both the live donor (LD) and deceased donor models in collaboration with the inaugural Swedish UTx team.
This is the first UTx procedure to occur in Australia, involving a mother donating her uterus to her daughter. The total operative time for the donor was 9 h 54 min. Concurrently, recipient surgery was synchronised to minimise graft ischaemic time, and the total operative time for the recipient was 6 h 12 min. Surgery was by laparotomy in the LD and recipient. The total warm ischaemic time of the graft was 1 h 53 min, and the cold ischaemic time was 2 h 17 min (total ischaemic time 4 h 10 min). The patient's first menstruation occurred 33 days after the UTx procedure.
Twenty-five years of Swedish and Australian collaboration has led to Australia's first successfully performed UTx surgery at The Royal Hospital for Women, Sydney, Australia.
报告澳大利亚首例子宫移植（UTx）的结果。
在瑞典和澳大利亚团队长期合作的基础上，获得了西悉尼地方卫生区 2019/ETH13038 号人类研究伦理委员会的批准，在一个合作的多地点研究中进行了六例 UTx 手术，包括澳大利亚皇家妇女医院、威尔士亲王医院和新南威尔士州的韦斯特米德医院。在与首届瑞典 UTx 团队合作的情况下，分别在活体供体（LD）和已故供体模型中批准了手术。
这是澳大利亚首例 UTx 手术，涉及母亲将子宫捐赠给女儿。供体的总手术时间为 9 小时 54 分钟。同时，为了尽量减少移植物缺血时间，对受体进行了同步手术，受体的总手术时间为 6 小时 12 分钟。LD 和受体均采用剖腹手术。移植物的总热缺血时间为 1 小时 53 分钟，冷缺血时间为 2 小时 17 分钟（总缺血时间为 4 小时 10 分钟）。患者在 UTx 手术后 33 天首次出现月经。
经过 25 年的瑞典和澳大利亚合作，澳大利亚首例成功的 UTx 手术在澳大利亚悉尼皇家妇女医院完成。
