结核 RNA 在骨与关节结核快速诊断中的临床实用性。
Clinical utility of tuberculosis RNA in the rapid diagnosis of bone and joint tuberculosis.
机构信息
Department of Orthopaedics, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine. Hangzhou, Zhejiang, China.
Department of Orthopaedics, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine. Hangzhou, Zhejiang, China.
出版信息
Diagn Microbiol Infect Dis. 2023 Jun;106(2):115941. doi: 10.1016/j.diagmicrobio.2023.115941. Epub 2023 Mar 14.
OBJECTIVES
To evaluate the diagnostic accuracy of tuberculosis RNA (TB-RNA) for the rapid diagnosis of bone and joint tuberculosis (BJTB).
METHODS
We conducted a retrospective study to evaluate the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of TB-RNA and acid-fast bacillus (AFB) smear against the final clinical diagnosis.
RESULTS
A total of 268 patients were included. The overall sensitivity, specificity, PPV, NPV, and AUC of AFB smear for BJTB were 0.7%, 100.0%, 100.0%, 49.3%, and 0.50, respectively, whereas those of TB-RNA were 59.6%, 100.0%, 100.0%, 70.6%, and 0.80, respectively; for cases of confirmed (culture-positive) BJTB, these values were 82.8%, 99.4%, 99.7%, 89.2%, and 0.91, respectively.
CONCLUSIONS
The diagnostic accuracy of TB-RNA in the rapid diagnosis of BJTB was relatively good, especially in culture-positive BJTB. The use of TB-RNA could be an effective technique for the rapid diagnosis of BJTB.
目的
评估结核 RNA（TB-RNA）在快速诊断骨与关节结核（BJTB）中的诊断准确性。
方法
我们进行了一项回顾性研究，以评估 TB-RNA 和抗酸杆菌（AFB）涂片相对于最终临床诊断的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和曲线下面积（AUC）。
结果
共纳入 268 例患者。AFB 涂片对 BJTB 的总体敏感性、特异性、PPV、NPV 和 AUC 分别为 0.7%、100.0%、100.0%、49.3%和 0.50，而 TB-RNA 分别为 59.6%、100.0%、100.0%、70.6%和 0.80；对于确诊（培养阳性）BJTB 病例，这些值分别为 82.8%、99.4%、99.7%、89.2%和 0.91。
结论
TB-RNA 在快速诊断 BJTB 中的诊断准确性相对较好，尤其是在培养阳性的 BJTB 中。TB-RNA 的使用可能是一种快速诊断 BJTB 的有效技术。
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