Chongqing Key Laboratory of Industrial Fermentation Microorganisms, College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China.
Int J Pharm. 2023 May 10;638:122923. doi: 10.1016/j.ijpharm.2023.122923. Epub 2023 Apr 7.
In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules.
在高剪切湿法制粒（HSWG）中，黏合剂和不同含糖量粉末之间的相互作用机制仍不清楚。本文通过 Kriging 模型和分子动力学（MD）模拟的实验分析相结合，从分子水平上研究了黏合剂和粉末之间的相互作用规律和机制。对于高含糖量的粘性粉末，黏合剂中的乙醇在将水分散到粉末中起着关键作用，而水量决定了颗粒的生长。在饱和阶段，降低糖含量有助于乙醇分子的渗透。在合并阶段，乙醇的浓度决定了混合物是否均匀混合。模拟结果与实际情况一致，解释了与黏合剂和粉末相互作用的竞争机制。因此，这项研究为深入了解粘性粉末的 HSWG 过程提供了一种有效的策略，并为中药（TCM）颗粒制剂的实际应用提供了指导。
