镉对淡水硬骨鱼条纹鲮脂鲤的影响：积累以及生化、遗传毒性和行为生物标志物
Cadmium effects on the freshwater teleost Prochilodus lineatus: Accumulation and biochemical, genotoxic, and behavioural biomarkers.
作者信息
Silva Alexandre Oliveira Fernandes da, Bezerra Vanessa, Meletti Paulo Cesar, Simonato Juliana Delatim, Martinez Claudia Bueno Dos Reis
机构信息
Departamento de Ciências Fisiológicas, Laboratório de Ecofisiologia Animal, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil; Centro de Ciências Humanas e da Educação, Universidade Estadual do Norte do Paraná (UENP), Jacarezinho, Paraná, Brazil.
Departamento de Ciências Fisiológicas, Laboratório de Ecofisiologia Animal, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
出版信息
Environ Toxicol Pharmacol. 2023 Apr;99:104121. doi: 10.1016/j.etap.2023.104121. Epub 2023 Apr 6.
In order to evaluate the effects of Cd, juveniles of the Neotropical fish Prochilodus lineatus were exposed to 1 and 10 μg L Cd, for 24 and 96 h. Fish exposed to Cd showed metal accumulation in the gills, kidney, and liver, an increase in DNA damage in erythrocytes, and an increase in lipid peroxidation (LPO) in the kidney. Cd exposure also caused a reduction in catalase activity, metallothionein induction, and LPO in the liver. Cd stimulated the swimming activity of exposed fish, resulting in longer swimming times and distances travelled, especially for the shortest exposure time. Changes in acetylcholinesterase activity (AChE) in the muscle and brain are probably related to these behavioural responses. These results show that Cd affects the functioning of several organs in P. lineatus, which is indicated by the genotoxic damage and changes in the AChE and swimming pattern of the exposed fish.
为了评估镉的影响，将新热带鱼细纹原唇齿脂鲤的幼鱼暴露于1和10μg/L的镉中，暴露时间分别为24小时和96小时。暴露于镉的鱼在鳃、肾脏和肝脏中出现金属积累，红细胞中的DNA损伤增加，肾脏中的脂质过氧化（LPO）增加。镉暴露还导致肝脏中的过氧化氢酶活性降低、金属硫蛋白诱导和LPO降低。镉刺激了暴露鱼的游泳活动，导致游泳时间和游动距离延长，尤其是在最短暴露时间时。肌肉和大脑中乙酰胆碱酯酶活性（AChE）的变化可能与这些行为反应有关。这些结果表明，镉会影响细纹原唇齿脂鲤多个器官的功能，这通过暴露鱼的遗传毒性损伤以及AChE和游泳模式的变化得以体现。
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