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[松果体细胞瘤——病例报告]

[Pineocytoma--a case report].

作者信息

Hattori T, Shinoda J, Kondo H, Ando T, Sakai N, Yamada H, Funakoshi T, Shimokawa K, Ikeda T

出版信息

No Shinkei Geka. 1986 Mar;14(3 Suppl):447-52.

PMID:3703149
Abstract

A report on a rare case of pineocytoma is presented. A 27-year-old woman visited our clinic because of a 3-month history of intermittent headaches and nausea. A CT scan revealed the presence of a marked obstructive hydrocephalus and mass without any contrast enhancement in the pineal region. Immediately, V-P shunting was performed and resulted in relief of all symptoms. Ventriculography showed a complete occlusion at the aqueductus Sylvii and filling defect at the posterior part of the 3rd ventricle. The patient was operated on in the prone position via infratentorial supracerebellar approach by suboccipital craniectomy on November 9, 1982. A grayish red-colored, well-defined solid tumor located at the pineal region was removed partially. The histopathological appearance of this tumor resembled the pattern of the normal pineal gland. Many cells exhibited a polar form, eosinophilic cytoplasm with the process often being directed toward a blood vessel. The cells around the central areas occupied by pale eosinophilic material were arranged like a "rosette". Combined chemo-radiotherapy was carried out after surgery. That is, a total dose of 4,825 rads to the whole brain was irradiated, and ACNU 140 mg and VCR 6 mg in total were administered intravenously and intermittently. After irradiation therapy, the tumor increased in size producing a ring-like enhancement effect as shown on repeated CT scans. During this time, she started to complain of blurred vision with Parinaud's sign. A second operation via interhemispheric approach by right parietal craniotomy was undergone, and the tumor was partially resected again on March 29, 1983.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本文报告一例罕见的松细胞瘤病例。一名27岁女性因间歇性头痛和恶心3个月前来我院就诊。CT扫描显示松果体区存在明显的梗阻性脑积水及肿块,无任何强化表现。随即进行了脑室-腹腔分流术,所有症状均得到缓解。脑室造影显示中脑导水管完全阻塞,第三脑室后部有充盈缺损。1982年11月9日,患者俯卧位,经枕下颅骨切除术采用幕下小脑上入路进行手术。部分切除了位于松果体区的灰红色、边界清晰的实性肿瘤。该肿瘤的组织病理学表现类似于正常松果体的模式。许多细胞呈极性形态,胞质嗜酸性,突起常指向血管。中央区域被淡嗜酸性物质占据,周围细胞呈“玫瑰花结”样排列。术后进行了联合放化疗。即对全脑进行总量4825拉德的照射,静脉间断给予总量140毫克的阿糖胞苷和6毫克的长春新碱。放疗后,肿瘤体积增大,在重复CT扫描中呈现环状强化效应。在此期间,她开始出现视力模糊及帕里诺德征。1983年3月29日,患者再次接受手术,经右顶叶开颅采用半球间入路,再次部分切除肿瘤。(摘要截取自250字)

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