Wistar大鼠视上核和室旁核中血管加压素mRNA含量的产后发育

Postnatal development of vasopressin mRNA content in supraoptic and paraventricular nucleus of the Wistar rat.

作者信息

van Tol H H, Snijdewint F G, Boer G J, Burbach J P

出版信息

Neurosci Lett. 1986 Mar 28;65(1):1-6. doi: 10.1016/0304-3940(86)90110-2.

Abstract

Levels of mRNA coding the vasopressin precursor (VP mRNA) were determined in the supraoptic and paraventricular nucleus during the first month of postnatal development of the Wistar rat by solution hybridization assay and Northern blot analysis. The supraoptic and paraventricular nuclei showed a marked increase in VP mRNA to adult levels during that period. These results indicate an upregulation of vasopressin gene expression in supraoptic and paraventricular nuclei after birth, a period in which vasopressin starts to become involved in kidney function.

摘要

通过溶液杂交分析和Northern印迹分析，测定了Wistar大鼠出生后第一个月发育期间视上核和室旁核中编码加压素前体的mRNA水平（VP mRNA）。在此期间，视上核和室旁核中的VP mRNA显著增加至成年水平。这些结果表明出生后视上核和室旁核中加压素基因表达上调，在此期间加压素开始参与肾脏功能。