Lin Mei-Chun, Chang Yung-Yee, Lee Yu, Wang Liang-Jen
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Kaohsiung 83301, Taiwan.
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Kaohsiung 83301, Taiwan.
World J Psychiatry. 2023 Mar 19;13(3):126-130. doi: 10.5498/wjp.v13.i3.126.
Tardive sensory syndrome (TSS) is a subtype of tardive syndrome (TS), and its etiology is still uncertain. Lurasidone is an atypical antipsychotic that has high affinity for dopamine D2- and serotonergic 5HT2A- and 5-HT7-receptors.
A 52-year-old woman, previously diagnosed with schizophrenia, and with no history of movement disorders and no sensory paresthesia, had taken lurasidone, initiate dose 40 mg daily then up titration to 120 mg daily, since March 2021, and developed mandibular sensory (pain) paresthesia after 3 mo of administration. After switching from lurasidone to quetiapine, she reported obvious impr-ovement in her mandibular pain.
It is noteworthy that TSS is a rare subtype of TS, and lurasidone, an atypical antipsychotic, usually has a lower risk of causing TS. In light of the temporal relationship, it is therefore concluded that use of lurasidone might have caused TSS in this patient. We reported this rare case as a reminder that clinicians should adopt a cautious approach when prescribing atypical antipsychotics, so as to prevent TS.
迟发性感觉综合征（TSS）是迟发性综合征（TS）的一种亚型，其病因仍不确定。鲁拉西酮是一种非典型抗精神病药物，对多巴胺D2受体、5-羟色胺能5HT2A受体和5-HT7受体具有高亲和力。
一名52岁女性，既往诊断为精神分裂症，无运动障碍病史及感觉异常，自2021年3月起服用鲁拉西酮，起始剂量为每日40mg，后逐渐增至每日120mg，用药3个月后出现下颌感觉（疼痛）异常。从鲁拉西酮换用喹硫平后，她报告下颌疼痛明显改善。
值得注意的是，TSS是TS的一种罕见亚型，非典型抗精神病药物鲁拉西酮通常引起TS的风险较低。鉴于时间关系，因此得出结论，该患者使用鲁拉西酮可能导致了TSS。我们报告这一罕见病例以提醒临床医生在开具非典型抗精神病药物时应谨慎，以预防TS。
