Zhang Jilei, Zhao Yixin, Jing Yuanyuan, Han Lin, Ma Xin, Yu Lisheng, Diao Tongxiang
Department of Otolaryngology-Head and Neck Surgery, Peking University People's Hospital, Beijing, China.
Front Neurol. 2023 Mar 24;14:980543. doi: 10.3389/fneur.2023.980543. eCollection 2023.
The purpose of this study was to measure the vestibular function and plasma fibrinogen level in the nitroglycerin (NTG)-induced chronic migraine rats, and explore the effect of defibrinogenation on migraine and associated vestibular dysfunction. The chronic migraine rat model was built by recurrent NTG injection. Batroxobin was administrated as a defibrinogenating drug. We measured the mechanical withdrawal threshold, vestibular function, and fibrinogen level of the rats 30 min before and 2 h following the model establishment, as well as 1 h after batroxobin administration. The results showed that vestibular function was impaired in NTG-induced chronic migraine rats. The fibrinogen levels were increased following repeated NTG injections. However, defibrinogenation did not affect either aggravating or alleviating mechanical hyperalgesia or vestibular dysfunction in the migraine model rats. These findings suggest that the NTG-induced chronic migraine rat model can be used for research on migraine-associated vestibular symptoms. Albeit the association between elevated fibrinogen levels and migraine attacks can be observed, the role of excessive fibrinogen in the pathogenesis of chronic migraine is yet to be determined.
本研究旨在测量硝酸甘油（NTG）诱导的慢性偏头痛大鼠的前庭功能和血浆纤维蛋白原水平，并探讨去纤维蛋白原对偏头痛及相关前庭功能障碍的影响。通过反复注射NTG建立慢性偏头痛大鼠模型。使用巴曲酶作为去纤维蛋白原药物。在模型建立前30分钟、建立后2小时以及巴曲酶给药后1小时，我们测量了大鼠的机械缩足阈值、前庭功能和纤维蛋白原水平。结果显示，NTG诱导的慢性偏头痛大鼠的前庭功能受损。反复注射NTG后纤维蛋白原水平升高。然而，去纤维蛋白原对偏头痛模型大鼠的机械性痛觉过敏加重或减轻以及前庭功能障碍均无影响。这些发现表明，NTG诱导的慢性偏头痛大鼠模型可用于偏头痛相关前庭症状的研究。尽管可以观察到纤维蛋白原水平升高与偏头痛发作之间的关联，但过量纤维蛋白原在慢性偏头痛发病机制中的作用尚待确定。
