Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
J Headache Pain. 2019 Aug 29;20(1):91. doi: 10.1186/s10194-019-1043-7.
Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life.
Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes.
Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.
偏头痛是一种常见的使人虚弱的疾病，其主要特征是严重的反复发作性头痛，伴有对光和声的敏感、恶心和呕吐。偏头痛相关的疼痛是其伴随残疾的主要原因，几乎会影响日常生活的方方面面。
我们对偏头痛头痛的神经生物学的理解的进步主要来自于利用偏头痛相关疼痛的小动物模型的基础科学研究。在本综述中，我们旨在描述几种常用的偏头痛临床前模型。我们将讨论触发和测量偏头痛相关疼痛表型的多种不同方法，并简要强调其中的特定优点和局限性。最后，我们将讨论潜在的未来挑战/机会，以完善现有的和开发新的偏头痛临床前模型，超越偏头痛相关疼痛，并扩展到偏头痛相关的替代表型。
有几个与头痛相关的疼痛的经过充分验证的动物模型，研究人员在选择最合适的模型来回答特定的研究问题之前，应该考虑每个模型的优点和局限性。此外，我们应该不断努力完善现有的和生成新的动物和非动物模型，这些模型有能力提高我们对头部疼痛以及原发性头痛障碍的非疼痛症状的理解。
