Nakata Takashi, Shindo Tomohiko, Ito Kenta, Eguchi Kumiko, Monma Yuto, Ichijo Sadamitsu, Ryoke Rie, Satoh Wakako, Kumasaka Kazunori, Sato Haruka, Kurosawa Ryo, Satoh Kimio, Kawashima Ryuta, Miura Masahito, Kanai Hiroshi, Yasuda Satoshi, Shimokawa Hiroaki
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Institute of Development, Aging and Cancer, Tohoku University Graduate School of Medicine, Sendai, Japan.
JACC Basic Transl Sci. 2022 Oct 12;8(3):283-297. doi: 10.1016/j.jacbts.2022.08.010. eCollection 2023 Mar.
Right ventricular failure (RVF) is a leading cause of death in patients with pulmonary hypertension; however, effective treatment remains to be developed. We have developed low-intensity pulsed ultrasound therapy for cardiovascular diseases. In this study, we demonstrated that the expression of endothelial nitric oxide synthase (eNOS) in RVF patients was downregulated and that eNOS expression and its downstream pathway were ameliorated through eNOS activation in 2 animal models of RVF. These results indicate that eNOS is an important therapeutic target of RVF, for which low-intensity pulsed ultrasound therapy is a promising therapy for patients with RVF.
右心室衰竭（RVF）是肺动脉高压患者死亡的主要原因；然而，仍有待开发有效的治疗方法。我们已经开发出用于心血管疾病的低强度脉冲超声疗法。在本研究中，我们证明了RVF患者内皮型一氧化氮合酶（eNOS）的表达下调，并且在2种RVF动物模型中通过eNOS激活改善了eNOS表达及其下游通路。这些结果表明，eNOS是RVF的重要治疗靶点，低强度脉冲超声疗法对RVF患者是一种有前景的治疗方法。
