Gui Jiaofeng, Li Yuqing, Liu Haiyang, Guo Lei-Lei, Li Jinlong, Lei Yunxiao, Li Xiaoping, Sun Lu, Yang Liu, Yuan Ting, Wang Congzhi, Zhang Dongmei, Li Jing, Liu Mingming, Hua Ying, Zhang Lin
Wannan Medical College.
Jinzhou Medical University.
Res Sq. 2023 Mar 28:rs.3.rs-2708175. doi: 10.21203/rs.3.rs-2708175/v1.
Middle-aged and elderly people in China probably suffer from hypertension. There is a close relationship between obesity-and lipid-related index and hypertension, which is recognized by recent studies. However, these studies have not systematically compared the relationship between the two. We aim to find the most effective obesity-and lipid-related index for predicting hypertension.
A total of 9488 middle-aged and elderly people in China participated in this study. In this study, the subjects were divided into male and female groups by the definition of the 2018 Chinese Guidelines for Prevention and Treatment of Hypertension. Searching for the best predictors among 13 obesity-and lipid-related indicators through binary logistic regression analyses and receiver operator curve (ROC). These 13 indicators are body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), conicity index (CI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), a body shape index (ABSI), body roundness index (BRI), triglyceride glucose index (TyG-index) and its correlation index (TyG-BMI, TyG-WC, TyG-WHtR).
After adjusting bias, all 13 indexes are risk factors for hypertension. In ROC curve analysis, thirteen obesity-and lipid-related factors can predict the occurrence of hypertension. Among them, CVAI has the best prediction effect (male: AUC = 0.660, female: AUC = 0.699). AUC for WHtR was equal to that for BRI and TyG - WHtR in identifying hypertension in male. Similarly, AUC of TyG-BMI and BMI were the same. In females, AUC for WHtR and BRI were the same when predicting hypertension. AUC of ABSI was much lower than other test indexes.
In predicting hypertension, thirteen obesity-and lipid-related factors are effective. In addition, in males and females, CVAI is the best indicator to indicate hypertension. TyG-WHtR, WHtR, and BRI performed well in predicting metabolic syndrome in both males and females. ABSI has a poor ability to predict hypertension.
中国中老年人可能患有高血压。肥胖及血脂相关指标与高血压之间存在密切关系，这已得到近期研究的认可。然而，这些研究尚未系统比较两者之间的关系。我们旨在找出预测高血压最有效的肥胖及血脂相关指标。
共有9488名中国中老年人参与本研究。在本研究中，根据《2018年中国高血压防治指南》的定义将受试者分为男性组和女性组。通过二元逻辑回归分析和受试者工作特征曲线（ROC）在13个肥胖及血脂相关指标中寻找最佳预测指标。这13个指标分别是体重指数（BMI）、腰围（WC）、腰高比（WHtR）、锥度指数（CI）、内脏脂肪指数（VAI）、中国内脏脂肪指数（CVAI）、脂质蓄积产物（LAP）、体型指数（ABSI）、体圆度指数（BRI）、甘油三酯葡萄糖指数（TyG指数）及其相关指数（TyG-BMI、TyG-WC、TyG-WHtR）。
校正偏倚后，所有13项指标均为高血压的危险因素。在ROC曲线分析中，13个肥胖及血脂相关因素均可预测高血压的发生。其中，CVAI的预测效果最佳（男性：AUC = 0.660，女性：AUC = 0.699）。在男性中，WHtR的AUC与BRI和TyG-WHtR在识别高血压时的AUC相等。同样，TyG-BMI和BMI的AUC相同。在女性中，预测高血压时WHtR和BRI的AUC相同。ABSI的AUC远低于其他检测指标。
在预测高血压方面，13个肥胖及血脂相关因素是有效的。此外，在男性和女性中，CVAI是指示高血压的最佳指标。TyG-WHtR、WHtR和BRI在预测男性和女性代谢综合征方面表现良好。ABSI预测高血压的能力较差。
