关于2019冠状病毒病对精液参数影响的系统评价。
A systematic review of the effect of COVID-19 on semen parameters.
作者信息
Lan Xiucheng, Wang Meijing, Yu Xujun, Dong Liang, Li Junjun, Chang Degui, Yang Fang
机构信息
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
出版信息
Heliyon. 2023 Apr;9(4):e14776. doi: 10.1016/j.heliyon.2023.e14776. Epub 2023 Mar 23.
BACKGROUND AND OBJECTIVES
Since the outbreak of COVID-19, more and more studies have proved that it has an impact on the male reproductive system. The purpose of this article is to investigate the effects of COVID-19 on male semen parameters, further analyze the incidence and risk factors of diseases related to semen parameters, and put forward to corresponding preventive measures.
METHODS
Retrieved from PubMed, Embase, The Cochrane Library, Web of Science, Clinicaltrails, CNKI, CBM, Wanfang Database and VIP to collect research on the effects of COVID-19 on the male reproductive system. The literature search was conducted until January 2022. In strict accordance with the inclusion and exclusion criteria, two researchers independently screened the literature and comprehensively analyzed five cohort studies on the impact of COVID-19 on male reproductive system. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included cohort studies, and Revman 5.4.1 was applied for statistical analysis.
RESULTS
Semen volume (RR = -0.10; 95% CI: 0.45, 0.26; P = 0.60), there was no significant difference between the test group and the control group; Sperm count (RR = -45.28; 95% CI: 66.38, 24.19; P = 0.0001), the sperm count of the COVID-19 test group was lower than that of the control group, and the difference was statistically significant; Sperm concentration (RR = -15.65 × 106; 95%CI: 31.52 × 106, 0.21 × 106; P = 0.05), there was no significant difference between the test group and the control group; progressive sperm motility (RR = 4.31; 95% CI: 4.62, 13.24; P = 0.34), there was no effect on progressive sperm motility in the COVID-19 test group compared with the control group.
CONCLUSIONS
COVID-19 can reduce semen quality and affect male fertility. However, due to the limitations of this study, this conclusion needs to be further verified by large-sample, high-quality prospective cohort studies on the long-term effects of COVID-19 on male reproductive function.
背景与目的
自新冠疫情爆发以来，越来越多的研究证明其对男性生殖系统有影响。本文旨在探讨新冠病毒对男性精液参数的影响，进一步分析与精液参数相关疾病的发病率及危险因素，并提出相应的预防措施。
方法
通过检索PubMed、Embase、Cochrane图书馆、Web of Science、Clinicaltrails、中国知网、中国生物医学文献数据库、万方数据库及维普数据库，收集关于新冠病毒对男性生殖系统影响的研究。文献检索截至2022年1月。严格按照纳入与排除标准，由两名研究人员独立筛选文献，并对5项关于新冠病毒对男性生殖系统影响的队列研究进行综合分析。采用纽卡斯尔-渥太华量表（NOS）评估纳入队列研究的质量，并应用Revman 5.4.1进行统计分析。
结果
精液量（RR = -0.10；95%CI：0.45，0.26；P = 0.60），试验组与对照组之间无显著差异；精子计数（RR = -45.28；95%CI：66.38，24.19；P = 0.0001），新冠病毒试验组的精子计数低于对照组，差异具有统计学意义；精子浓度（RR = -15.65×10⁶；95%CI：31.52×10⁶；0.21×10⁶；P = 0.05），试验组与对照组之间无显著差异；前向运动精子活力（RR = 4.31；95%CI：4.62，13.24；P = 0.34），与对照组相比，新冠病毒试验组对前向运动精子活力无影响。
结论
新冠病毒可降低精液质量并影响男性生育能力。然而，由于本研究存在局限性，这一结论需要通过关于新冠病毒对男性生殖功能长期影响的大样本、高质量前瞻性队列研究进一步验证。
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