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巨噬细胞在抗小鼠锥虫免疫中的作用。

The role of the macrophage in immunity to Trypanosoma musculi.

作者信息

Ferrante A

出版信息

Parasite Immunol. 1986 Mar;8(2):117-27. doi: 10.1111/j.1365-3024.1986.tb00838.x.

DOI:10.1111/j.1365-3024.1986.tb00838.x
PMID:3703568
Abstract

Trypanosoma musculi was killed by adherent peritoneal exudate cells which had the typical appearance of macrophages. Observations by light and electron microscopy showed that the trypanosomes were phagocytozed and killed intracellularly within phagocytic vacuoles of mouse macrophages. Adherence, phagocytosis and killing of T. musculi required the presence of serum from mice immune to this parasite. Phagocytosis and killing of T. musculi was highly dependent on heat-labile factors in immune mouse serum.

摘要

鼠锥虫被具有典型巨噬细胞外观的黏附性腹膜渗出细胞杀死。光镜和电镜观察显示，锥虫被小鼠巨噬细胞的吞噬泡吞噬并在细胞内被杀死。鼠锥虫的黏附、吞噬和杀伤需要对该寄生虫免疫的小鼠血清的存在。鼠锥虫的吞噬和杀伤高度依赖于免疫小鼠血清中的热不稳定因子。

相似文献

1
The role of the macrophage in immunity to Trypanosoma musculi.巨噬细胞在抗小鼠锥虫免疫中的作用。
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Role of hypochlorous acid in Trypanosoma musculi killing by phagocytes.
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Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism.巨噬细胞对鼠锥虫的细胞抑制作用涉及一种依赖L-精氨酸的机制。
J Immunol. 1991 Jun 15;146(12):4338-43.

引用本文的文献

1
Immunological and nonimmunological control of severity of Trypanosoma musculi infections in C3H and C57BL/6 inbred mice.C3H和C57BL/6近交系小鼠中肌肉锥虫感染严重程度的免疫和非免疫控制
Infect Immun. 1989 Jun;57(6):1647-55. doi: 10.1128/iai.57.6.1647-1655.1989.
2
Failure to demonstrate a major role for Kupffer cells and radiosensitive leukocytes in immunoglobulin-mediated elimination of Trypanosoma musculi.未能证明库普弗细胞和放射敏感白细胞在免疫球蛋白介导的消除鼠锥虫过程中起主要作用。
Infect Immun. 1990 Jun;58(6):1971-8. doi: 10.1128/iai.58.6.1971-1978.1990.
3
Cells within the vascular system capable of mediating trypanocidal activity in vitro.
血管系统中能够在体外介导杀锥虫活性的细胞。
Infect Immun. 1991 Sep;59(9):3143-50. doi: 10.1128/iai.59.9.3143-3150.1991.