Newson J, Naessens J, Stagg D A, Black S J
Parasite Immunol. 1986 Mar;8(2):149-58. doi: 10.1111/j.1365-3024.1986.tb00841.x.
Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine lymphoid cells but not on any uninfected bovine lymphoid cells. Inoculation of allogeneic recipient cattle with T.p. lawrencei-transformed cells bearing the J7 determinant resulted in transfer of the parasite but not of the J7 epitope to the recipients' own cells. The presence of the J7 determinant could not be correlated with the parasite phenotype nor with the surface phenotype of the infected cells. It is therefore not known whether the J7 epitope is of parasite origin or whether it is a bovine differentiation antigen modified by the presence of the parasite.
尝试制备针对感染泰勒虫劳伦斯亚种（Theileria parva lawrencei）的牛淋巴细胞表面寄生虫编码或诱导抗原的特异性单克隆抗体，结果鉴定出了单克隆抗体J7。该抗体可识别一些感染了劳伦斯泰勒虫的牛淋巴样细胞上的一种膜糖蛋白，但未感染的牛淋巴样细胞上没有。用携带J7决定簇的劳伦斯泰勒虫转化细胞接种同种异体受体牛，结果寄生虫转移到了受体自身细胞，但J7表位未转移。J7决定簇的存在与寄生虫表型或感染细胞的表面表型均无关联。因此，尚不清楚J7表位是源于寄生虫，还是寄生虫存在导致修饰的牛分化抗原。
