Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cell Biochem Funct. 2023 Jun;41(4):392-398. doi: 10.1002/cbf.3792. Epub 2023 Apr 10.
Autophagy is a physiological event in mammalian cells to promote cell survival and efficiency in tissues, but it may turn to be a pathological process in disease conditions such as in diabetes. Chronic hyperglycemia induces aberrant autophagy and promotes cellular death as a main underlying cause of diabetes-related complications. Therefore, autophagy-modifying therapy may be of value to prevent the development of complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of newly introduced antidiabetic drugs that achieve normoglycemia through causing overt glycosuria. There is evidence that these drugs may have pleiotropic extra-glycemic benefits, but their effect on the autophagy process is unclear; therefore, this review was undertaken to clarify the possible effects of SGLT2is on autophagy.
自噬是哺乳动物细胞中的一种生理现象，可促进组织中的细胞存活和效率，但在糖尿病等疾病状态下可能会转变为病理过程。慢性高血糖会诱导异常自噬，并促进细胞死亡，这是糖尿病相关并发症的主要潜在原因。因此，自噬修饰疗法可能具有预防并发症发展的价值。钠-葡萄糖共转运蛋白 2 抑制剂（SGLT2is）是一类新引入的抗糖尿病药物，通过引起明显的糖尿来实现血糖正常化。有证据表明，这些药物可能具有多种血糖控制以外的益处，但它们对自噬过程的影响尚不清楚；因此，进行了这项综述以阐明 SGLT2is 对自噬的可能影响。
