Dykes F D, Ahmann P A, Baldzer K, Carrigan T A, Kitney R, Giddens D P
Pediatr Res. 1986 Apr;20(4):301-8. doi: 10.1203/00006450-198604000-00005.
The relationship between heart rate variability and respiration patterns was investigated using spectral analysis techniques in nine full-term infants whose ages ranged from 39-75 h. All the infants were studied during sleep, although no attempt was made to classify rapid eye movement or nonrapid eye movement states prospectively. The data obtained were examined to determine which aspects of neonatal breathing patterns are correlated with heart rate variability. Three spectral regions of heart rate variability could be identified: a very low frequency region below 0.02 Hz; a low frequency region from 0.02-0.20 Hz; and a high frequency region above 0.20 Hz. The dominant heart rate variability activity in these neonates was seen in the very low and low frequency regions, with little activity in the high frequency regions. In contrast to older infants and adults, respiration and heart rate variability were not strongly related through a high frequency region respiratory sinus arrhythmia but rather through a breath amplitude sinus arrhythmia which occurs in the low frequency region of the spectrum. The prominent very low frequency activity and the low frequency activity ascribed to breath amplitude modulation may result from autonomic nervous system mediation of chemoregulation.
利用频谱分析技术，对9名年龄在39至75小时的足月儿的心率变异性与呼吸模式之间的关系进行了研究。所有婴儿均在睡眠期间接受研究，不过未尝试前瞻性地对快速眼动或非快速眼动状态进行分类。对所获得的数据进行检查，以确定新生儿呼吸模式的哪些方面与心率变异性相关。心率变异性可分为三个频谱区域：低于0.02赫兹的极低频区域；0.02至0.20赫兹的低频区域；以及高于0.20赫兹的高频区域。这些新生儿的主要心率变异性活动出现在极低频和低频区域，高频区域的活动很少。与大龄婴儿和成人不同，呼吸与心率变异性并非通过高频区域的呼吸性窦性心律不齐密切相关，而是通过频谱低频区域出现的呼吸幅度性窦性心律不齐密切相关。归因于呼吸幅度调制的显著极低频活动和低频活动可能是由自主神经系统对化学调节的介导作用导致的。
