Longin Elke, Gerstner Thorsten, Schaible Thomas, Lenz Tamara, König Stephan
Children's Hospital, University of Mannheim, Germany.
J Perinat Med. 2006;34(4):303-8. doi: 10.1515/JPM.2006.058.
Heart rate variability (HRV) reveals information on the functional state of the autonomic nervous system (ANS). This study was initiated to assess the physiological- and maturational development of the ANS by comparing HRV data of healthy prematures with term infants.
Short-term recordings of HRV in 39 premature healthy infants (29-35 weeks' gestation) were performed and compared with normative data of term infants. Frequency domain HRV parameters are computed in three frequency bands.
Gestational age of newborn infants is correlated with HRV. Prematures showed significant lower HRV parameters than term infants. The most significant differences were discerned for HRV parameters reflecting parasympathetic activity, whereas the pulse of the baro-receptor reflex was similar for prematures and term infants at 0.07 Hz (0.1 Hz adults). A respiratory peak in the HF-band according to respiratory sinus arrhythmia (RSA), as is common in adults, was not detected for prematures as it is not detected in term infants.
Maturation of the ANS is accompanied by increasing HRV with a pronounced increase of parasympathetic activity. These changes are measurable by short-term recordings. The physiological pulses concerning baroreceptor reflex activity and respiratory modulation were similar in prematures and term infants.
心率变异性（HRV）揭示自主神经系统（ANS）功能状态的信息。本研究旨在通过比较健康早产儿和足月儿的HRV数据来评估ANS的生理和成熟发育情况。
对39名健康早产儿（孕29 - 35周）进行HRV短期记录，并与足月儿的标准数据进行比较。在三个频段计算频域HRV参数。
新生儿的胎龄与HRV相关。早产儿的HRV参数显著低于足月儿。反映副交感神经活动的HRV参数差异最为显著，而早产儿和足月儿在0.07 Hz（成人0.1 Hz）时压力感受器反射的脉冲相似。与成人常见情况一样，早产儿未检测到根据呼吸性窦性心律不齐（RSA）在高频段出现的呼吸峰值，足月儿也未检测到。
ANS的成熟伴随着HRV的增加以及副交感神经活动的显著增加。这些变化可通过短期记录测量。早产儿和足月儿在压力感受器反射活动和呼吸调节方面的生理脉冲相似。
