Unfolding the mechanism of hepatocyte injury of HBV precore and core promoter variants.
作者信息
Jilg Nikolaus, Baumert Thomas F
机构信息
Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
出版信息
Hepatology. 2023 Sep 1;78(3):702-705. doi: 10.1097/HEP.0000000000000400. Epub 2023 Apr 11.
Abstract
摘要
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HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.
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