LC3B 是 LMX1B 介导的多巴胺能神经元自噬基因转录的辅助因子。

LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons.

机构信息

Department of Medical Biology, Autophagy Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

出版信息

J Cell Biol. 2023 May 1;222(5). doi: 10.1083/jcb.202303008. Epub 2023 Apr 10.

DOI:10.1083/jcb.202303008

PMID:37036692

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10097974/

Abstract

It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jiménez-Moreno et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for LMX1B-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons.

摘要

越来越明显的是，自噬蛋白 Atg8 家族不仅在细胞质中发挥作用，而且在细胞核中也发挥作用。在本期杂志中，Jiménez-Moreno 等人（2023. J. Cell Biol.https://doi.org/10.1083/jcb.201910133）报告称，核 LC3B 与 LIM 同源域转录因子 LMX1B 结合，并作为 LMX1B 介导的自噬基因转录的辅助因子发挥作用，为中脑多巴胺能神经元提供应激保护并确保其存活。