Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
Semin Neurol. 2023 Apr;43(2):187-194. doi: 10.1055/s-0043-1767714. Epub 2023 Apr 10.
Neurologic symptoms have been reported in over 30% of hospitalized patients with coronavirus disease 2019 (COVID-19), but the pathogenesis of these symptoms remains under investigation. Here, we place the neurologic complications of COVID-19 within the context of three historical viral pandemics that have been associated with neurologic diseases: (1) the 1918 influenza pandemic, subsequent spread of encephalitis lethargica, and lessons for the study of COVID-19-related neuroinflammation; (2) the controversial link between the 1976 influenza vaccination campaign and Guillain-Barré Syndrome and its implications for the post- and parainfectious complications of COVID-19 and COVID-19 vaccination; and (3) potential applications of scientific techniques developed in the wake of the human immunodeficiency virus pandemic to the study of postacute sequelae of COVID-19.
神经系统症状在超过 30%的 2019 冠状病毒病（COVID-19）住院患者中都有报告，但这些症状的发病机制仍在研究中。在这里，我们将 COVID-19 的神经系统并发症置于与神经系统疾病相关的三次历史病毒大流行的背景下：（1）1918 年流感大流行、随后昏睡性脑炎的传播，以及对 COVID-19 相关神经炎症研究的教训；（2）1976 年流感疫苗接种运动与格林-巴利综合征之间的争议性联系，以及其对 COVID-19 和 COVID-19 疫苗接种后的和副感染性并发症的影响；（3）人类免疫缺陷病毒大流行后开发的科学技术在 COVID-19 后急性后遗症研究中的潜在应用。
