Ornell Felipe, Scherer Juliana N, Schuch Jaqueline B, Sordi Anne O, Halpern Silvia C, Rebelatto Fernando P, Bristot Giovana, Kapczinski Flavio, Roglio Vinicius S, Pechansky Flavio, Kessler Felix H P, von Diemen Lisia
Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Alcohol. 2023 Sep;111:1-7. doi: 10.1016/j.alcohol.2023.04.001. Epub 2023 Apr 8.
Brain-derived neurotrophic factor (BDNF) is involved in several drug-induced brain neuroadaptations. The impact of withdrawal from substances that have different neurological mechanisms on BDNF levels is unclear. Our goal was to compare serum BDNF levels in inpatients with alcohol or crack cocaine use disorders during the early withdrawal period, and to evaluate the association with substance-related outcomes. We performed a follow-up study with 101 men under detoxification treatment (drug preference: alcohol [n = 37] and crack cocaine [n = 64]). Blood samples were collected on the 1st and 15th days of hospitalization to measure serum BDNF levels. Serum BDNF levels increased during the early stage of withdrawal (28.2 ± 10.0 vs. 32.6 ± 13.3, p < 0.001), similarly in individuals with alcohol and crack cocaine use. In the alcohol group, BDNF levels on the 15th day of hospitalization were negatively correlated with age (r = -0.394, p = 0.023). Delta BDNF levels were also negatively correlated with BDNF on the 1st day of hospitalization (p = 0.011). No significant correlation was found regarding substance-related outcomes. This is the first study to compare BDNF levels in alcohol and crack cocaine users undergoing similar treatment conditions. These findings could be related to clinical improvement after abstinence or even to drug withdrawal itself, decreasing neuronal injury. Furthermore, age may be a crucial factor, hindering the recovery of neuroplasticity in alcohol users.
脑源性神经营养因子（BDNF）参与多种药物诱导的脑内神经适应性变化。不同神经机制的物质戒断对BDNF水平的影响尚不清楚。我们的目标是比较酒精或快克可卡因使用障碍住院患者在早期戒断期间的血清BDNF水平，并评估其与物质相关结局的关联。我们对101名接受戒毒治疗的男性进行了一项随访研究（药物偏好：酒精[n = 37]和快克可卡因[n = 64]）。在住院第1天和第15天采集血样以测量血清BDNF水平。戒断早期血清BDNF水平升高（28.2±10.0对32.6±13.3，p < 0.001），酒精和快克可卡因使用者情况相似。在酒精组中，住院第15天的BDNF水平与年龄呈负相关（r = -0.394，p = 0.023）。BDNF变化水平也与住院第1天的BDNF呈负相关（p = 0.011）。未发现与物质相关结局有显著相关性。这是第一项比较处于相似治疗条件下酒精和快克可卡因使用者BDNF水平的研究。这些发现可能与戒断后的临床改善甚至与药物戒断本身有关，可减少神经元损伤。此外，年龄可能是一个关键因素，会阻碍酒精使用者神经可塑性的恢复。
