Fulinara Christian P, Huynh Alina, Goldwater Deena, Abdalla Basmah, Schaenman Joanna
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Divisions of Geriatrics and Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
J Transplant. 2023 Apr 1;2023:1510259. doi: 10.1155/2023/1510259. eCollection 2023.
Frailty is often defined as a decrease in physiological reserve and has been shown to be correlated with adverse health outcomes and mortality in the general population. This condition is highly prevalent in the chronic kidney disease (CKD) patient population as well as in kidney transplant (KT) recipients. Other age-associated changes include sarcopenia, nutrition, cognition, and depression. In assessing the contributions of these components to patient outcomes and their prevalence in the CKD and KT patient population, it can be determined how such variables may be associated with frailty and the extent to which they may impact the adverse outcomes an individual may experience.
We sought to perform a systematic literature review to review published data on frailty and associated age-associated syndromes in CKD and KT patients.
Over 80 references pertinent to frailty, sarcopenia, nutrition, cognition, or depression in patients with CKD or KT were identified. Systematic review was performed to evaluate the data supporting the use of the following approaches: Fried Frailty, Short Physical Performance Battery, Frailty Index, Sarcopenia Index, CT scan quantification of muscle mass, health-related quality of life, and assessment tools for nutrition, cognition, and depression.
This report represents a comprehensive review of previously published research articles on this topic. The intersectionality between all these components in contributing to the patient's clinical status suggests a need for a multifaceted approach to developing comprehensive care and treatment for the CKD and KT population to improve outcomes before and after transplantation.
衰弱通常被定义为生理储备的下降，并且已被证明与普通人群的不良健康结局和死亡率相关。这种情况在慢性肾脏病（CKD）患者群体以及肾移植（KT）受者中非常普遍。其他与年龄相关的变化包括肌肉减少症、营养、认知和抑郁。在评估这些因素对患者结局的影响及其在CKD和KT患者群体中的患病率时，可以确定这些变量与衰弱的关联方式以及它们可能影响个体不良结局的程度。
我们试图进行一项系统的文献综述，以回顾已发表的关于CKD和KT患者衰弱及相关年龄相关综合征的数据。
确定了80多篇与CKD或KT患者的衰弱、肌肉减少症、营养、认知或抑郁相关的参考文献。进行了系统综述以评估支持使用以下方法的数据：弗里德衰弱评估法、简短体能状况量表、衰弱指数、肌肉减少症指数、肌肉量的CT扫描量化、健康相关生活质量以及营养、认知和抑郁的评估工具。
本报告对先前发表的关于该主题的研究文章进行了全面综述。所有这些因素在影响患者临床状况方面的交叉性表明，需要采取多方面的方法为CKD和KT人群制定全面的护理和治疗方案，以改善移植前后的结局。
