School of Pharmacy, Lanzhou University, Lanzhou, Gansu, China.
Department of Pharmacy, The 940th Hospital Joint Logistics Support Force of the Chinese People's Liberation Army, Lanzhou, China.
Curr Drug Metab. 2023;24(2):106-113. doi: 10.2174/1389200224666230405115442.
Epigenetic modification refers to the heritable changes caused by chromosomal changes without changing the DNA sequence. Epigenetics runs through the entire growth and differentiation process of the body, which causes varied diseases. Hypoxia is a physiological astate of lowered partial oxygen partial pressure that affects cell and tissue function. Transporters are proteins that maintain a normal and stable state of cells. Transporter's expression levels when hypoxia occurs influence the absorption, distribution, metabolism, and excretion of drugs, thereby affecting the utilization and efficacy of drugs. Epigenetic modification is assumed to play an important role in the metabolism of drugs. Changes in epigenetic modification and transporter expression levels under hypoxia are explored in our work, and the effect of epigenetic modification on transporter expression and how this regulatory mechanism works and affects drugs under hypoxia are questioned. It is important for drug development, treatment of diseases and rational use of drugs.
表观遗传修饰是指染色体变化引起的可遗传变化，而不改变 DNA 序列。表观遗传学贯穿于身体的整个生长和分化过程，导致各种疾病。缺氧是指局部氧分压降低的生理状态，影响细胞和组织功能。转运蛋白是维持细胞正常和稳定状态的蛋白质。当发生缺氧时，转运蛋白的表达水平会影响药物的吸收、分布、代谢和排泄，从而影响药物的利用和疗效。假设表观遗传修饰在药物代谢中起着重要作用。我们的工作探讨了缺氧下表观遗传修饰和转运蛋白表达水平的变化，以及表观遗传修饰对转运蛋白表达的影响，以及这种调节机制在缺氧下如何工作并影响药物。这对于药物开发、疾病治疗和合理用药非常重要。
