Langhans W, Scharrer E, Geary N
Physiol Behav. 1986;36(3):483-7. doi: 10.1016/0031-9384(86)90319-7.
We tested whether pancreatic glucagon's effects on satiety and hepatic glycogenolysis depend on variations in the macronutrient composition of the diet. Rats were kept on high carbohydrate, high fat, or high protein diets (HC-, HF- or HP-rats, respectively) and adapted to a 5 hour feeding (11:00-16:00)-19 hour deprivation (16:00-11:00) schedule. Glucagon (540 mcg/kg body weight) was intraperitoneally injected at 14:00. Glucagon stimulated similar amounts of hepatic glycogenolysis in HC- and in HF-rats and less glycogenolysis in HP-rats, but glucagon decreased food intake only in HC-rats. When HF- or HP-rats were prefed the HC-diet once for 1 hour (11:00-12:00) prior to injection, glucagon stimulated hepatic glycogenolysis similarly in both groups but decreased food intake only in HF-rats. Therefore, stimulation of hepatic glycogenolysis by glucagon is not sufficient to elicit satiety under all feeding conditions. The results also suggest that glucagon-induced satiety is not limited to carbohydrate intake.
我们测试了胰高血糖素对饱腹感和肝糖原分解的影响是否取决于饮食中常量营养素组成的变化。将大鼠分别置于高碳水化合物、高脂肪或高蛋白饮食（分别为HC-、HF-或HP-大鼠）中，并使其适应5小时进食（11:00 - 16:00）- 19小时禁食（16:00 - 11:00）的时间表。在14:00腹腔注射胰高血糖素（540微克/千克体重）。胰高血糖素在HC-大鼠和HF-大鼠中刺激相似量的肝糖原分解，而在HP-大鼠中刺激的糖原分解较少，但胰高血糖素仅在HC-大鼠中减少食物摄入量。当HF-或HP-大鼠在注射前一次给予1小时（11:00 - 12:00）的HC-饮食时，胰高血糖素在两组中刺激肝糖原分解的程度相似，但仅在HF-大鼠中减少食物摄入量。因此，在所有进食条件下，胰高血糖素对肝糖原分解的刺激不足以引发饱腹感。结果还表明，胰高血糖素诱导的饱腹感不限于碳水化合物摄入。
