铁死亡：在压力下！

Ferroptosis: Under pressure!

机构信息

Institute of Metabolism and Cell Death, Helmholtz Center Munich, Neuherberg, Germany; Division of Gynecological Oncology, National Center of Tumor Diseases (NCT), and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Institute of Metabolism and Cell Death, Helmholtz Center Munich, Neuherberg, Germany.

出版信息

Curr Biol. 2023 Apr 10;33(7):R269-R272. doi: 10.1016/j.cub.2023.03.009.

DOI:10.1016/j.cub.2023.03.009

PMID:37040709

Abstract

Ferroptosis is a disease-relevant and pervasive form of cell death triggered by iron-dependent lipid peroxidation and resulting in membrane rupture. A new study addresses how tension-sensing channels can balance and modulate membrane tension in the context of ferroptotic cell death.

摘要

铁死亡是一种与疾病相关的、普遍存在的细胞死亡形式，由铁依赖性脂质过氧化引发，并导致膜破裂。一项新的研究探讨了张力感应通道如何在铁死亡细胞死亡的背景下平衡和调节膜张力。