Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, Pengjiang District, Jiangmen, 529030, Guangdong Province, China.
Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, Guangdong Province, China.
BMC Public Health. 2023 Apr 11;23(1):679. doi: 10.1186/s12889-023-15442-z.
According to research, the fatty liver index (FLI) is associated with diabetes. However, few studies have been conducted to investigate the relationship between FLI and diabetes risk from various perspectives. This study comprehensively investigated the relationship between FLI and incident diabetes in a large Japanese population.
This retrospective cohort study included 14,280 participants from Murakami Memorial Hospital in Japan from 2004 to 2015. The independent and dependent variables are FLI and risk of type 2 diabetes mellitus (T2DM), respectively. To examine the link between FLI and incident T2DM, Cox proportional-hazards regression was employed. In addition, we performed a number of sensitivity studies to guarantee the validity of the results. Moreover, we conducted subgroup analyses.
After adjusting covariates, the results showed that FLI was positively associated with the risk of T2DM (HR = 1.019, 95%CI: 1.012, 1.025). Additionally, the sensitivity analysis showed how reliable the outcomes were. And a stronger association between FLI and incident T2DM was observed in the regular exercisers (HR = 1.036, 95%CI: 1.019-1.053, P < 0.0001) and the population without ethanol consumption (HR = 1.028, 95%CI: 1.017-1.039, P < 0.0001). Besides, receiver operating characteristic (ROC) curve analysis showed that FLI was better than waist circumference, triglycerides, body mass index, and gamma-glutamyl transferase in predicting incident T2DM.
FLI is positively associated with incident T2DM.
研究表明，脂肪肝指数（FLI）与糖尿病有关。然而，从多个角度研究 FLI 与糖尿病风险之间的关系的研究较少。本研究综合考察了日本大型人群中 FLI 与 2 型糖尿病（T2DM）发病风险之间的关系。
本回顾性队列研究纳入了日本村上纪念医院 2004 年至 2015 年期间的 14280 名参与者。独立变量和因变量分别为 FLI 和 2 型糖尿病风险（T2DM）。为了检验 FLI 与 T2DM 发病风险之间的关系，采用 Cox 比例风险回归模型。此外，我们还进行了多项敏感性研究以确保结果的有效性。此外，我们还进行了亚组分析。
调整协变量后，结果表明 FLI 与 T2DM 发病风险呈正相关（HR=1.019，95%CI：1.012，1.025）。敏感性分析表明结果的可靠性。在经常运动者（HR=1.036，95%CI：1.019-1.053，P<0.0001）和不饮酒人群（HR=1.028，95%CI：1.017-1.039，P<0.0001）中，FLI 与 T2DM 发病风险之间的相关性更强。此外，受试者工作特征（ROC）曲线分析表明，FLI 在预测 T2DM 发病风险方面优于腰围、甘油三酯、体重指数和γ-谷氨酰转移酶。
FLI 与 T2DM 发病风险呈正相关。
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