Price Rebecca B, Ferrarelli Fabio, Hanlon Colleen, Gillan Claire M, Kim Tae, Siegle Greg J, Wallace Meredith L, Renard Marlee, Kaskie Rachel, Degutis Michelle, Wears Anna, Brown Vanessa, Rengasamy Manivel, Ahmari Susanne E
Department of Psychiatry, University of Pittsburgh.
Department of Psychology, University of Pittsburgh.
Clin Psychol Sci. 2023 Jan;11(1):77-89. doi: 10.1177/21677026221103136. Epub 2022 Jul 29.
Compulsive behaviors (CBs) have been linked to orbitofrontal cortex (OFC) function in animal and human studies. However, brain regions function not in isolation but as components of widely distributed brain networks-such as those indexed via resting-state functional connectivity (RSFC). Sixty-nine individuals with CB disorders were randomized to receive a single session of neuromodulation targeting the left OFC-intermittent theta-burst stimulation (iTBS) or continuous TBS (cTBS)-followed immediately by computer-based behavioral "habit override" training. OFC seeds were used to quantify RSFC following iTBS and following cTBS. Relative to cTBS, iTBS showed increased RSFC between right OFC (Brodmann's area 47) and other areas, including dorsomedial prefrontal cortex (dmPFC), occipital cortex, and a priori dorsal and ventral striatal regions. RSFC connectivity effects were correlated with OFC/frontopolar target engagement and with subjective difficulty during habit-override training. Findings help reveal neural network-level impacts of neuromodulation paired with a specific behavioral context, informing mechanistic intervention development.
在动物和人类研究中，强迫行为（CBs）与眶额皮质（OFC）功能有关。然而，脑区并非独立发挥作用，而是作为广泛分布的脑网络的组成部分，例如通过静息态功能连接（RSFC）索引的那些网络。69名患有CB障碍的个体被随机分配接受针对左侧OFC的单次神经调节——间歇性theta爆发刺激（iTBS）或连续TBS（cTBS），随后立即进行基于计算机的行为“习惯克服”训练。使用OFC种子来量化iTBS后和cTBS后的RSFC。相对于cTBS，iTBS显示右侧OFC（布罗德曼区47）与其他区域之间的RSFC增加，包括背内侧前额叶皮质（dmPFC）、枕叶皮质以及先验的背侧和腹侧纹状体区域。RSFC连接效应与OFC/额极靶点参与度以及习惯克服训练期间的主观难度相关。研究结果有助于揭示神经调节与特定行为背景配对时在神经网络层面的影响，为机制性干预开发提供信息。
