Dehghani Zobeideh, Mahdavi Seyed Mohammad, Modarresi Chahardehi Amir, Mansouri Vahid, Jahani Sherafat Somayeh
Department of Bioscience and Biotechnology, Malek Ashtar University of Technology (MUT), Tehran, Iran.
Cognitive Neuroscience Research Center, AJA University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2022 Nov 28;13:e52. doi: 10.34172/jlms.2022.52. eCollection 2022.
Fear memories are influenced by psychological and environmental variables. We evaluated the effect of 2.45 GHz microwave radiation on rats' fear learning and memory ability to determine the potential risks. The present study aimed to assess the impacts of corticosterone (CORT) levels on the consolidation and reconsolidation of fear conditioning memories. The rats were evaluated in contextual fear conditioning using foot shocks in both short-term (7 days) exposure and long-term (30 days) exposure. Young male Wistar rats were continually exposed to radio frequency electromagnetic field radiation for 5-6 weeks (1 h/day) with a frequency, power density, and pulse width of 2.45 GHz, 6.0 mW/cm, and 2 ms, respectively. Several animals housed in identical conditions without exposure to radiation were monitored. Based on the results, a significant increase and decrease in body weight and percentage of the freezing time were observed after the short-term group respectively. However, in the long term, we observed no significant difference in body weight, and the freezing time decreased substantially. As CORT levels were analyzed, long-term radiation might increase stress, which was associated with significant weight loss in rats.
恐惧记忆受心理和环境变量的影响。我们评估了2.45吉赫兹微波辐射对大鼠恐惧学习和记忆能力的影响，以确定潜在风险。本研究旨在评估皮质酮（CORT）水平对恐惧条件反射记忆巩固和重新巩固的影响。在短期（7天）暴露和长期（30天）暴露中，使用足部电击对大鼠进行情境恐惧条件反射评估。将年轻雄性Wistar大鼠连续5至6周（每天1小时）暴露于射频电磁场辐射下，其频率、功率密度和脉冲宽度分别为2.45吉赫兹、6.0毫瓦/平方厘米和2毫秒。监测几只饲养在相同条件下未暴露于辐射的动物。根据结果，短期组大鼠体重显著增加而后下降，冻结时间百分比也出现相应变化。然而，长期来看，我们观察到体重无显著差异，且冻结时间大幅下降。在分析CORT水平时发现，长期辐射可能会增加应激，这与大鼠体重显著减轻有关。
