汇合的血管平滑肌细胞培养物中潜在致死性辐射损伤的存活与修复
Survival and repair of potentially lethal radiation damage in confluent vascular smooth muscle cell cultures.
作者信息
Rosen E M, Goldberg I D, Myrick K V, Halpin P A, Levenson S E
出版信息
Radiother Oncol. 1986 Feb;5(2):159-63. doi: 10.1016/s0167-8140(86)80170-0.
PMID:3704190
Abstract
Confluent cultures of rat aortic smooth muscle cells demonstrated dose-dependent potentially lethal damage repair (PLDR), with an average repair factor of 4 for a 10 Gy dose. PLDR occurred with a half-time of 2 hours and was nearly maximal by 8 h. Among other factors, PLDR may contribute to the radioresistance of large blood vessels.
摘要
大鼠主动脉平滑肌细胞的融合培养物表现出剂量依赖性的潜在致死性损伤修复（PLDR），10 Gy剂量时的平均修复因子为4。PLDR的半衰期为2小时，8小时时接近最大值。在其他因素中，PLDR可能导致大血管的放射抗性。
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