术前单核细胞与高密度脂蛋白比值作为胃癌患者根治性切除术后生存结局的预测指标

Preoperative monocyte to high-density lipoprotein ratio as a predictor of survival outcome of gastric cancer patients after radical resection.

作者信息

Wu Huadong, Zhang Jinjia, Zhou Baojun, Ma Shaowei, Zheng Yu

机构信息

Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Department of General Practice, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

出版信息

Biomark Med. 2023 Feb;17(3):123-131. doi: 10.2217/bmm-2022-0691. Epub 2023 Apr 12.

DOI:10.2217/bmm-2022-0691

PMID:37042447

Abstract

This study aimed to verify the prognostic value of monocyte to high-density lipoprotein ratio (MHR) in gastric cancer patients after radical resection. The Cox proportional hazards model was used to determine the risk variables for survival. Older age (>60 years) (hazard ratio [HR]: 1.832; 95% CI: 1.167-2.725; p = 0.009), advanced tumor node metastasis stage (p < 0.05), lymphatic invasion (HR: 1.639; 95% CI: 1.114-3.032; p < 0.05), vascular invasion (HR: 2.002; 95% CI: 1.246-5.453; p = 0.028) and high MHR (HR: 1.154; 95% CI: 1.062-2.315; p = 0.021) were independent poor prognostic factors for gastric cancer patients after radical resection. Older age, advanced tumor node metastasis stage, lymphatic invasion, vascular invasion and high MHR were independent poor prognostic factors for gastric cancer patients after radical resection.

摘要

本研究旨在验证单核细胞与高密度脂蛋白比值（MHR）在胃癌根治术后患者中的预后价值。采用Cox比例风险模型确定生存的风险变量。年龄较大（>60岁）（风险比[HR]：1.832；95%置信区间：1.167 - 2.725；p = 0.009）、肿瘤淋巴结转移分期较晚（p < 0.05）、淋巴侵犯（HR：1.639；95%置信区间：1.114 - 3.032；p < 0.05）、血管侵犯（HR：2.002；95%置信区间：1.246 - 5.453；p = 0.028）以及高MHR（HR：1.154；95%置信区间：1.062 - 2.315；p = 0.021）是胃癌根治术后患者独立的不良预后因素。年龄较大、肿瘤淋巴结转移分期较晚、淋巴侵犯、血管侵犯和高MHR是胃癌根治术后患者独立的不良预后因素。