Department of Dermatology, Renaissance School of Medicine at Stony, Brook University, Stony Brook, NY, 11727, USA.
Arch Dermatol Res. 2023 Oct;315(8):2261-2269. doi: 10.1007/s00403-023-02619-0. Epub 2023 Apr 12.
Atopic dermatitis (AD) is a highly pruritic, inflammatory skin disease with a strong immune component. Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes synovitis and destruction of small joints. Researchers have attempted to quantify an association between both diseases with mixed conclusions. This systematic review and meta-analysis will study the association between AD and RA. Additionally, we conducted a systematic review between AD and other arthritic conditions including osteoarthritis (OA), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Medline, Web of Science, Cochrane, and EMBASE databases were searched for relevant studies from inception to March 2021. Observational studies examining relationships between AD and arthritic conditions were selected. 2539 studies were screened; nine were found suitable for quantitative analysis, all of which examined AD and RA. All studies had low risk of bias as determined by the Newcastle-Ottawa Scale. Patients with RA did not have significantly increased odds of comorbid AD. These findings were consistent across multiple study designs. However, patients with AD had significantly increased odds of comorbid RA. There were not enough studies identified to perform quantitative analysis between AD and other arthritic conditions. Two studies, one on JIA and one PsA, found no association with AD. Two studies on AD and OA had conflicting results. The present study provides definitive evidence of increased odds of comorbid RA in AD patients. There were no such increased odds of comorbid AD in RA patients. No such association was found between AD and PsA, OA or JIA.
特应性皮炎（AD）是一种高度瘙痒、炎症性皮肤病，具有强烈的免疫成分。类风湿关节炎（RA）是一种系统性自身免疫性疾病，可引起滑膜炎和小关节破坏。研究人员试图定量评估这两种疾病之间的关联，但结论不一。本系统评价和荟萃分析将研究 AD 与 RA 之间的关联。此外，我们还对 AD 与其他关节炎疾病（包括骨关节炎（OA）、银屑病关节炎（PsA）和幼年特发性关节炎（JIA））之间的关系进行了系统评价。从建库到 2021 年 3 月，我们在 Medline、Web of Science、Cochrane 和 EMBASE 数据库中搜索了相关研究。选择了观察性研究，以检查 AD 和关节炎疾病之间的关系。共筛选了 2539 项研究，其中 9 项适合进行定量分析，均研究了 AD 和 RA。所有研究的偏倚风险均较低，均由纽卡斯尔-渥太华量表确定。患有 RA 的患者并发 AD 的几率没有显著增加。这些发现与多种研究设计一致。然而，患有 AD 的患者并发 RA 的几率显著增加。没有足够的研究来对 AD 和其他关节炎疾病之间进行定量分析。两项研究，一项针对 JIA，一项针对 PsA，均未发现与 AD 有关。两项关于 AD 和 OA 的研究结果相互矛盾。本研究提供了明确的证据，表明 AD 患者并发 RA 的几率增加。RA 患者并发 AD 的几率没有增加。在 AD 与 PsA、OA 或 JIA 之间未发现这种关联。
