长链非编码 RNA-NEAT1 促进人类癌症进展的研究进展更新综述。

An updated review of contribution of long noncoding RNA-NEAT1 to the progression of human cancers.

机构信息

Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, Doha 26999, Qatar.

出版信息

Pathol Res Pract. 2023 May;245:154380. doi: 10.1016/j.prp.2023.154380. Epub 2023 Feb 24.

DOI:10.1016/j.prp.2023.154380

PMID:37043964

Abstract

Long non-coding RNAs (lncRNAs) present pivotal roles in cancer tumorigenesis and progression. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1) as a lncRNA has been shown to mediate cell proliferation, migration, and EMT in tumor cells. NEAT1 by targeting several miRNAs/mRNA axes could regulate cancer cell behavior. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of some human cancers. In this review, we summarized various NEAT1-related signaling pathways that are critical in cancer initiation and progression.

摘要

长链非编码 RNA（lncRNAs）在癌症的发生和发展中起着关键作用。最近，核斑装配转录本 1（NEAT1）作为一种 lncRNA，已被证明可以介导肿瘤细胞的增殖、迁移和 EMT。NEAT1 通过靶向几个 miRNA/mRNA 轴，可以调节癌细胞的行为。因此，NEAT1 可能作为某些人类癌症的预测和治疗的有效生物标志物。在这篇综述中，我们总结了在癌症发生和发展中起关键作用的各种与 NEAT1 相关的信号通路。