Kibler Artur, Seifert Marc, Budeus Bettina
Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany.
Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany; Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine University, Düsseldorf, Germany.
Immunol Lett. 2023 Apr-May;256-257:59-65. doi: 10.1016/j.imlet.2023.04.003. Epub 2023 Apr 10.
In this review, we will summarize the growing body of knowledge on the age-related changes of human splenic B cell composition and molecular evidence of immune maturation and discuss the contribution of these changes on splenic protective function. From birth on, the splenic marginal zone (sMZ) contains a specialized B cell subpopulation, which recruits and archives memory B cells from immune responses throughout the organism. The quality of sMZ B cell responses is augmented by germinal center (GC)-dependent maturation of memory B cells during childhood, however, in old age, these mechanisms likely contribute to waning of splenic protective function.
在本综述中，我们将总结关于人类脾脏B细胞组成随年龄变化的不断增长的知识体系以及免疫成熟的分子证据，并讨论这些变化对脾脏保护功能的作用。从出生起，脾脏边缘区（sMZ）就包含一个特殊的B细胞亚群，该亚群从全身的免疫反应中募集并储存记忆B细胞。儿童期生发中心（GC）依赖的记忆B细胞成熟增强了sMZ B细胞反应的质量，然而，在老年时，这些机制可能导致脾脏保护功能的衰退。
