Kasahun Abebaw Wasie, Zewdie Amare, Shitu Solomon, Alemayehu Girma
Department of Public Health, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.
Department of Midwifery, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.
J Pharm Policy Pract. 2023 Apr 12;16(1):55. doi: 10.1186/s40545-023-00560-1.
Administration of potent vaccine in a manner of well-maintained cold chain system is one of the public health focus areas in developing regions of the world. Health professionals' adherence towards good vaccine cold chain management practices is an important element to ensure potent vaccine reached to users. Studies on health professionals' practice on vaccine cold chain maintenance and associated factors in Ethiopia have shown wide variations. The aim of this systematic review and meta-analysis is to produce the overall/pooled prevalence of health professionals' good vaccine cold chain management practice and to identify its associated factors in Ethiopia.
Systematic review and meta-analysis was conducted on vaccine cold chain management practice and associated factors among health professionals in Ethiopia. Literature search was made on international data bases using medical subject heading and key words. Data were extracted using Microsoft excel and imported to STATA version 17 for analysis. Heterogeneity was checked using Cochrane Q test and I statistics. Weighted inverse variance random effect model was used to estimate the pooled level of good vaccine cold chain management practice among health professionals. Publication bias was checked using funnel plot and using Egger's test.
A total of ten studies were included in the review. The overall/pooled prevalence of good vaccine cold chain management practice in Ethiopia is 27.48% with 95% CI (25.70-29.26). Having good knowledge on vaccine cold chain management AOR 2.27 95% CI (1.72-2.99), and have received on-job training AOR 6.64 95% CI (4.60-9.57) are factors positively associated with vaccine cold chain management practice among health professionals in Ethiopia.
The overall/pooled prevalence of good vaccine cold chain management practice is much lower than the expected level. There is a need to plan on-job trainings for all vaccine handlers and other health professionals supposed to work on vaccination program.
以维护良好的冷链系统方式接种强效疫苗是世界发展中地区公共卫生重点关注领域之一。卫生专业人员对良好疫苗冷链管理规范的遵守是确保强效疫苗送达使用者的重要因素。关于埃塞俄比亚卫生专业人员在疫苗冷链维护方面的实践及相关因素的研究显示出很大差异。本系统评价和荟萃分析的目的是得出埃塞俄比亚卫生专业人员良好疫苗冷链管理实践的总体/合并患病率，并确定其相关因素。
对埃塞俄比亚卫生专业人员的疫苗冷链管理实践及相关因素进行系统评价和荟萃分析。使用医学主题词和关键词在国际数据库中进行文献检索。使用Microsoft excel提取数据，并导入STATA 17版本进行分析。使用Cochrane Q检验和I统计量检查异质性。采用加权逆方差随机效应模型估计卫生专业人员中良好疫苗冷链管理实践的合并水平。使用漏斗图和Egger检验检查发表偏倚。
该评价共纳入10项研究。埃塞俄比亚良好疫苗冷链管理实践的总体/合并患病率为27.48%，95%置信区间为（25.70 - 29.26）。对疫苗冷链管理有良好认知（比值比2.27，95%置信区间为1.72 - 2.99）以及接受过在职培训（比值比6.64，95%置信区间为4.60 - 9.57）是与埃塞俄比亚卫生专业人员疫苗冷链管理实践呈正相关的因素。
良好疫苗冷链管理实践的总体/合并患病率远低于预期水平。有必要为所有疫苗接种人员以及其他应参与疫苗接种计划工作的卫生专业人员安排在职培训。
