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[快速进展性颅内大动脉粥样硬化，一种罕见的卒中病因]

[Rapidly progressive intracranial large artery aterosclerosis, a rare stroke etiology].

作者信息

Sarria-Estrada S, Antón-Jiménez A, Martínez-Sáez E, Tortajada-Bustelo J C, Rovira A

机构信息

Hospital Universitari Vall d'Hebron, 08035 Barcelona, España.

出版信息

Rev Neurol. 2023 Apr 16;76(8):273-275. doi: 10.33588/rn.7608.2022328.

DOI:10.33588/rn.7608.2022328
PMID:37046396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10478135/
Abstract

INTRODUCTION

Intracranial atheromatosis is one of the most frequent causes of stroke. It is usually a slowly progressive process and normally associated with the sum of vascular risk factors.

CASE REPORT

In this case we present a rapidly progressive development of intracranial atheromatosis demonstrated by serial neuroimaging techniques and sample analysis in a 72-year-old female patient with high levels of interleukin-6 and C-reactive protein, with no signs of vasculitis.

CONCLUSION

Rapidly progressive intracranial atheromatosis should be considered in adult patients over 50 years of age with recurrent stroke.

摘要

引言

颅内动脉粥样硬化是中风最常见的病因之一。它通常是一个缓慢进展的过程，通常与血管危险因素的总和相关。

病例报告

在本病例中，我们通过系列神经影像学技术和样本分析展示了一名72岁女性患者颅内动脉粥样硬化的快速进展，该患者白细胞介素-6和C反应蛋白水平高，无血管炎迹象。

结论

50岁以上反复中风的成年患者应考虑快速进展性颅内动脉粥样硬化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10478135/05ed4b6ed8dd/RN-76-273-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10478135/05ed4b6ed8dd/RN-76-273-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5def/10478135/05ed4b6ed8dd/RN-76-273-g001.jpg

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本文引用的文献

1
Black blood imaging of intracranial vessel walls.颅内血管壁的黑血成像
Pract Neurol. 2020 Dec 29. doi: 10.1136/practneurol-2020-002806.
2
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.脑释放的危险信号和应激反应协同作用，加速中风后的动脉粥样硬化进展。
Sci Transl Med. 2018 Mar 14;10(432). doi: 10.1126/scitranslmed.aao1313.
3
The Use and Pitfalls of Intracranial Vessel Wall Imaging: How We Do It.颅内血管壁成像的应用与陷阱：我们如何应用。
Radiology. 2018 Jan;286(1):12-28. doi: 10.1148/radiol.2017162096.
4
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.急性脑卒中的神经保护：靶向兴奋性毒性、氧化应激和硝化应激以及炎症。
Lancet Neurol. 2016 Jul;15(8):869-881. doi: 10.1016/S1474-4422(16)00114-9. Epub 2016 May 11.
5
Recurrent ischemic events in young adults after first-ever ischemic stroke.青年首次缺血性脑卒中后反复发作的缺血性事件。
Ann Neurol. 2010 Nov;68(5):661-71. doi: 10.1002/ana.22091.
6
Progression of symptomatic intracranial large artery atherosclerosis is associated with a proinflammatory state and impaired fibrinolysis.有症状的颅内大动脉粥样硬化进展与促炎状态和纤溶功能受损有关。
Stroke. 2008 May;39(5):1456-63. doi: 10.1161/STROKEAHA.107.498600. Epub 2008 Mar 6.