Cho Jooyoung, Lee Jong-Han, Lee Dong Hyun, Kim Juwon, Uh Young
Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.
Center for Precision Medicine and Genomics, Wonju Severance Christian Hospital, Wonju 26426, Republic of Korea.
Diagnostics (Basel). 2023 Mar 23;13(7):1213. doi: 10.3390/diagnostics13071213.
(1) Background: We compared the diagnostic and prognostic performance of serum amyloid A (SAA), procalcitonin (PCT), delta neutrophil index (DNI), and C-reactive protein (CRP) in patients with hematologic diseases; (2) Methods: We retrospectively collected the remaining serum samples from patients with hematologic diseases, analyzed their clinical data, and measured the levels of PCT, DNI, CRP, and SAA. Performances for infection diagnosis were evaluated using a receiver operating characteristic curve analysis, and 90-day mortality was analyzed using Kaplan-Meier estimation; (3) Results: The levels of all markers were significantly higher in the infected group ( = 27) than those in the uninfected group ( = 100) ( < 0.0001 for all markers). The areas under the curve for diagnosing infection for PCT, DNI, CRP, and SAA were 0.770, 0.817, 0.870, and 0.904, respectively. Increased PCT levels were associated with higher mortality ( = 0.0250); this association was not observed with other examined markers; (4) Conclusions: CRP and SAA exhibited greater discriminative power for infection than PCT. However, only PCT levels were positively associated with 90-day mortality. Herein, we evaluated the diagnostic performance of the four markers. Additional studies are needed to confirm the findings of the present study and validate the potential of these markers in clinical practice.
(1) 背景：我们比较了血清淀粉样蛋白A（SAA）、降钙素原（PCT）、中性粒细胞指数变化值（DNI）和C反应蛋白（CRP）在血液病患者中的诊断和预后性能；(2) 方法：我们回顾性收集了血液病患者剩余的血清样本，分析了他们的临床数据，并测量了PCT、DNI、CRP和SAA的水平。使用受试者工作特征曲线分析评估感染诊断性能，并使用Kaplan-Meier估计法分析90天死亡率；(3) 结果：感染组（n = 27）所有标志物的水平均显著高于未感染组（n = 100）（所有标志物P < 0.0001）。PCT、DNI、CRP和SAA诊断感染的曲线下面积分别为0.770、0.817、0.870和0.904。PCT水平升高与较高的死亡率相关（P = 0.0250）；其他检测标志物未观察到这种相关性；(4) 结论：CRP和SAA对感染的鉴别能力高于PCT。然而，只有PCT水平与90天死亡率呈正相关。在此，我们评估了这四种标志物的诊断性能。需要进一步的研究来证实本研究的结果，并验证这些标志物在临床实践中的潜力。
