各种白细胞介素对常见心脏病中原始细胞类型的病理生理影响。
Pathophysiological Effects of Various Interleukins on Primary Cell Types in Common Heart Disease.
机构信息
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan 430062, China.
Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, Hubei University, Wuhan 430062, China.
出版信息
Int J Mol Sci. 2023 Mar 30;24(7):6497. doi: 10.3390/ijms24076497.
Myocardial infarction (MI), heart failure, cardiomyopathy, myocarditis, and myocardial ischemia-reperfusion injury (I/R) are the most common heart diseases, yet there is currently no effective therapy due to their complex pathogenesis. Cardiomyocytes (CMs), fibroblasts (FBs), endothelial cells (ECs), and immune cells are the primary cell types involved in heart disorders, and, thus, targeting a specific cell type for the treatment of heart disease may be more effective. The same interleukin may have various effects on different kinds of cell types in heart disease, yet the exact role of interleukins and their pathophysiological pathways on primary cell types remain largely unexplored. This review will focus on the pathophysiological effects of various interleukins including the IL-1 family (IL-1, IL-18, IL-33, IL-37), IL-2, IL-4, the IL-6 family (IL-6 and IL-11), IL-8, IL-10, IL-17 on primary cell types in common heart disease, which may contribute to the more precise and effective treatment of heart disease.
心肌梗死（MI）、心力衰竭、心肌病、心肌炎和心肌缺血再灌注损伤（I/R）是最常见的心脏病，但由于其发病机制复杂，目前尚无有效的治疗方法。心肌细胞（CMs）、成纤维细胞（FBs）、内皮细胞（ECs）和免疫细胞是心脏疾病中主要涉及的细胞类型，因此针对特定细胞类型进行心脏疾病治疗可能更为有效。同一种白细胞介素可能对心脏疾病中不同类型的细胞具有不同的作用，但白细胞介素的确切作用及其在主要细胞类型中的病理生理途径在很大程度上仍未得到探索。本综述将重点介绍各种白细胞介素的病理生理作用，包括白细胞介素 1 家族（IL-1、IL-18、IL-33、IL-37）、白细胞介素 2、白细胞介素 4、白细胞介素 6 家族（IL-6 和 IL-11）、白细胞介素 8、白细胞介素 10、白细胞介素 17 在常见心脏病中的主要细胞类型中的作用，这可能有助于更精确和有效地治疗心脏病。
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