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细胞对 DNA 损伤的反应：从 DNA 修复到多倍体及其他。

The Cellular Response to DNA Damage: From DNA Repair to Polyploidy and Beyond.

机构信息

Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.

出版信息

Int J Mol Sci. 2023 Apr 6;24(7):6852. doi: 10.3390/ijms24076852.

DOI:10.3390/ijms24076852
PMID:37047822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10095034/
Abstract

A major challenge in treating patients with solid tumors is posed by intratumor heterogeneity, with different sub-populations of cancer cells within the same tumor exhibiting therapy resistance through different biological processes [...].

摘要

治疗实体瘤患者的一个主要挑战是肿瘤内异质性，同一肿瘤内的不同亚群癌细胞通过不同的生物学过程表现出治疗抵抗性[...]。

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