细胞对 DNA 损伤的反应：从 DNA 修复到多倍体及其他。
The Cellular Response to DNA Damage: From DNA Repair to Polyploidy and Beyond.
机构信息
Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.
出版信息
Int J Mol Sci. 2023 Apr 6;24(7):6852. doi: 10.3390/ijms24076852.
Abstract
A major challenge in treating patients with solid tumors is posed by intratumor heterogeneity, with different sub-populations of cancer cells within the same tumor exhibiting therapy resistance through different biological processes [...].
摘要
治疗实体瘤患者的一个主要挑战是肿瘤内异质性，同一肿瘤内的不同亚群癌细胞通过不同的生物学过程表现出治疗抵抗性[...]。
相似文献
1
The Cellular Response to DNA Damage: From DNA Repair to Polyploidy and Beyond.
Int J Mol Sci. 2023 Apr 6;24(7):6852. doi: 10.3390/ijms24076852.
2
Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence.
Int J Mol Sci. 2020 Feb 15;21(4):1308. doi: 10.3390/ijms21041308.
3
Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.
J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.
4
Bleomycin-induced DNA damage and repair in Xenopus laevis and Xenopus tropicalis.
J Exp Zool A Ecol Genet Physiol. 2007 Feb 1;307(2):84-90. doi: 10.1002/jez.a.339.
5
Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice.
Hepatology. 2003 Oct;38(4):958-66. doi: 10.1053/jhep.2003.50421.
6
The DNA damage response: implications for tumor responses to radiation and chemotherapy.
Annu Rev Med. 2015;66:129-43. doi: 10.1146/annurev-med-081313-121208. Epub 2014 Nov 24.
7
Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.
Mol Neurobiol. 2016 Apr;53(3):1808-1823. doi: 10.1007/s12035-015-9139-9. Epub 2015 Mar 11.
8
Beyond repair foci: subnuclear domains and the cellular response to DNA damage.
Cell Cycle. 2007 Aug 1;6(15):1864-72. doi: 10.4161/cc.6.15.4560. Epub 2007 Jun 11.
9
10
DNA Damage Response and Metabolic Reprogramming in Health and Disease.
Trends Genet. 2020 Oct;36(10):777-791. doi: 10.1016/j.tig.2020.06.018. Epub 2020 Jul 17.
引用本文的文献
1
Anastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors.
Int J Mol Sci. 2025 Feb 22;26(5):1881. doi: 10.3390/ijms26051881.
2
Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells.
Oncogene. 2023 Oct;42(41):3047-3061. doi: 10.1038/s41388-023-02813-4. Epub 2023 Aug 26.
本文引用的文献
1
What Are the Reasons for Continuing Failures in Cancer Therapy? Are Misleading/Inappropriate Preclinical Assays to Be Blamed? Might Some Modern Therapies Cause More Harm than Benefit?
Int J Mol Sci. 2022 Oct 30;23(21):13217. doi: 10.3390/ijms232113217.
2
The 'war on cancer' isn't yet won.
Nature. 2022 Jan;601(7893):297. doi: 10.1038/d41586-022-00109-3.
3
Polyploid giant cancer cells: An emerging new field of cancer biology.
Semin Cancer Biol. 2022 Jun;81:1-4. doi: 10.1016/j.semcancer.2021.10.006. Epub 2021 Oct 22.
4
The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability.
Int J Mol Sci. 2021 Mar 15;22(6):2976. doi: 10.3390/ijms22062976.
5
Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?
Int J Mol Sci. 2020 Nov 29;21(23):9090. doi: 10.3390/ijms21239090.
6
The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer.
Int J Mol Sci. 2020 Nov 23;21(22):8877. doi: 10.3390/ijms21228877.
7
Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer.
Int J Mol Sci. 2020 Nov 19;21(22):8759. doi: 10.3390/ijms21228759.
8
Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.
Int J Mol Sci. 2020 Aug 24;21(17):6084. doi: 10.3390/ijms21176084.
9
"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
Int J Mol Sci. 2020 Apr 16;21(8):2779. doi: 10.3390/ijms21082779.
10
XPA: DNA Repair Protein of Significant Clinical Importance.
Int J Mol Sci. 2020 Mar 22;21(6):2182. doi: 10.3390/ijms21062182.
Zotero 插件