Kal Magdalena, Winiarczyk Mateusz, Zarębska-Michaluk Dorota, Odrobina Dominik, Cieśla Elżbieta, Płatkowska-Adamska Bernadetta, Biskup Michał, Pabjan Paweł, Głuszek Stanisław, Mackiewicz Jerzy
Collegium Medicum, Jan Kochanowski University of Kielce, 25-369 Kielce, Poland.
Ophthalmic Clinic, The Voivodeship Hospital, 25-736 Kielce, Poland.
J Clin Med. 2023 Mar 27;12(7):2528. doi: 10.3390/jcm12072528.
The purpose of this study was to evaluate the persistent changes in microvascular parameters based on optical coherence tomography angiography (OCTA) in patients hospitalized due to COVID-19 bilateral pneumonia. The case-control prospective study was carried out among 49 patients with COVID-19 and 45 healthy age- and gender-matched 2 and 8 months after hospital discharge. We found a significantly decreased vessel density (VD) in superficial capillary plexus (SCP) in COVID-19 patients. Significantly decreased vessel density (VD) in the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and choriocapillaris (CC), with significantly increased vessel density observed in the choriocapillaris in the foveal area (FCC). The foveal avascular zone in DCP (FAZd) was significantly increased in the COVID-19 group. We found differences between OCTA parameters according to gender. The foveal VD in SCP and DCP was significantly decreased in women compared to men. The FAZ area in SCP (FAZs) and superior VD in the choriocapillaris (SCC) were significantly increased in women. In conclusion, we noticed persistent changes in the ocular parameters of OCTA in COVID-19 patients. At the second follow-up visit, we observed a widened FAZ zone in SCP and decreased VD in some regions of the retina and choroid.
本研究的目的是基于光学相干断层扫描血管造影（OCTA）评估因新型冠状病毒肺炎双侧肺炎住院患者微血管参数的持续变化。这项病例对照前瞻性研究在49例新型冠状病毒肺炎患者和45例年龄及性别匹配的健康对照者出院后2个月和8个月进行。我们发现新型冠状病毒肺炎患者浅表毛细血管丛（SCP）的血管密度（VD）显著降低。浅表毛细血管丛（SCP）、深层毛细血管丛（DCP）和脉络膜毛细血管（CC）的血管密度（VD）显著降低，而在黄斑区脉络膜毛细血管（FCC）观察到血管密度显著增加。新型冠状病毒肺炎组DCP中的黄斑无血管区（FAZd）显著增加。我们发现OCTA参数存在性别差异。与男性相比，女性SCP和DCP中的黄斑VD显著降低。女性SCP中的FAZ面积（FAZs）和脉络膜毛细血管中的上方VD（SCC）显著增加。总之，我们注意到新型冠状病毒肺炎患者OCTA的眼部参数存在持续变化。在第二次随访时，我们观察到SCP中的FAZ区增宽，视网膜和脉络膜某些区域的VD降低。
