视网膜色素变性患者中通过按扇区测量视乳头周围血管密度预测中心视野恶化

Prediction of central visual field deterioration by sector-wise peripapillary vessel density measurement in eyes with retinitis pigmentosa.

作者信息

Okawa Kazuyoshi, Iwashita Yume, Inoue Tatsuya, Kawasaki Shohei, Uechi Yuna, Miyazato Misa, Nakamura Kentaro, Asaoka Ryo, Maruyama-Inoue Maiko, Yanagi Yasuo, Kadonosono Kazuaki

机构信息

Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.

Department of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

出版信息

Int Ophthalmol. 2025 Jul 22;45(1):310. doi: 10.1007/s10792-025-03677-1.

DOI:10.1007/s10792-025-03677-1

PMID:40694149

Abstract

PURPOSE

To investigate the relationship between the visual field (VF) deterioration and vessel density (VD) around the optic nerve head (ONH) in a sector-wise manner in eyes with retinitis pigmentosa (RP).

METHODS

The present study enrolled the RP patients who demonstrated VF constriction within central 10°. The VD around the ONH was measured with optical coherence tomography angiography (OCTA), using three binarization methods and the relationships between VD and the mean deviation (MD) value were investigated, respectively. Then, the VD in each quadrant (superior, temporal, inferior, nasal) around the ONH was calculated using Otsu method (OVDs: vessel density measured with Otsu method in the superior region, OVDt: vessel density measured with Otsu method in the temporal region, OVDi: vessel density measured with Otsu method in the inferior region, OVDn: vessel density measured with Otsu method in the nasal region). Considering the foveal position relative to the optic disc, angle-corrected binarized OCTA images were created and the VD was measured in each sector (AcOVDs: angle-corrected OVDs, AcOVDt: angle-corrected OVDt, AcOVDi: angle-corrected OVDi, and AcOVDn: angle-corrected OVDn). We investigated the relationship between the MD value and OVDs, OVDt, OVDi and OVDn. Furthermore, the correlation between the MD value and AcOVDs, AcOVDt, AcOVDi and AcOVDn was analyzed.

RESULTS

Thirty-six eyes were examined in the current study. Among Niblack, Bernsen and Otsu methods, the VD measured with Otsu method was closely related to the MD value. Among OVDs, OVDt, OVDi and OVDn, the optimal model for the MD value included OVDt and OVDi. On the other hand, among AcOVDs, AcOVDt, AcOVDi and AcOVDn, the optimal model for the MD value included only AcOVDt.

CONCLUSIONS

The sector-wise VD around the ONH reflects VF deficit severity and is a candidate for improving the assessment of VF deterioration in eyes with RP.

摘要

目的

以扇形方式研究视网膜色素变性（RP）患者视神经乳头（ONH）周围视野（VF）恶化与血管密度（VD）之间的关系。

方法

本研究纳入了中心10°范围内出现VF收缩的RP患者。使用光学相干断层扫描血管造影（OCTA），采用三种二值化方法测量ONH周围的VD，并分别研究VD与平均偏差（MD）值之间的关系。然后，使用大津法计算ONH周围每个象限（上方、颞侧、下方、鼻侧）的VD（OVDs：上方区域用大津法测量的血管密度，OVDt：颞侧区域用大津法测量的血管密度，OVDi：下方区域用大津法测量的血管密度，OVDn：鼻侧区域用大津法测量的血管密度）。考虑到黄斑相对于视盘的位置，创建角度校正的二值化OCTA图像，并在每个扇形区域测量VD（AcOVDs：角度校正的OVDs，AcOVDt：角度校正的OVDt，AcOVDi：角度校正的OVDi，AcOVDn：角度校正的OVDn）。我们研究了MD值与OVDs、OVDt、OVDi和OVDn之间的关系。此外，分析了MD值与AcOVDs、AcOVDt、AcOVDi和AcOVDn之间的相关性。