Research Unit of Food Science and Human Nutrition, Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21-00128 Roma, Italy.
Research Unit of Gastroenterology, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21-00128 Roma, Italy.
Nutrients. 2023 Mar 28;15(7):1647. doi: 10.3390/nu15071647.
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. The pathogenesis of IBS is not completely clear, but it is known to be multifactorial and complex. Endogenous and exogenous factors such as abnormal GI motility, low-grade inflammation, increased epithelial permeability and visceral hypersensitivity, but diet and psychosocial aspects are also recognized as important actors. Furthermore, the interaction between diet and gut microbiota has gained interest as a potential contributor to the pathophysiology of IBS. To date, there is no specific diet for IBS with constipation (IBS-C); however, many studies show that fiber intake, especially soluble fiber such as inulin, could have a positive effect on symptoms. This review aims to evaluate the effects of some nutritional components such as fibers but also functional foods, prebiotics, probiotics and symbiotics on symptoms and microbiota in IBS-C subjects.
肠易激综合征（IBS）是一种慢性功能性胃肠道疾病，其特征为与排便相关的腹痛或排便习惯改变。IBS 的发病机制尚不完全清楚，但已知其是多因素和复杂的。内源性和外源性因素，如异常的胃肠道动力、低度炎症、上皮通透性增加和内脏高敏性，但饮食和心理社会方面也被认为是重要的因素。此外，饮食和肠道微生物群的相互作用已被认为是 IBS 病理生理学的一个潜在因素。迄今为止，没有针对便秘型肠易激综合征（IBS-C）的特定饮食；然而，许多研究表明，膳食纤维的摄入，特别是菊粉等可溶性纤维，可能对症状有积极影响。本综述旨在评估一些营养成分（如纤维）以及功能性食品、益生元、益生菌和合生菌对 IBS-C 患者症状和肠道微生物群的影响。
