Bărboi Oana-Bogdana, Chirilă Ioan, Ciortescu Irina, Anton Carmen, Drug Vasile-Liviu
Department of Gastroenterology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Institute of Gastroenterology and Hepatology, 'Saint Spiridon' Hospital, 700111 Iasi, Romania.
J Clin Med. 2022 Apr 17;11(8):2248. doi: 10.3390/jcm11082248.
(1) Background: Irritable bowel syndrome (IBS) is a common disease, with multiple pathophysiological mechanisms involved. A single treatment for all the patients with IBS is not possible. Prebiotics may have a beneficial effect on IBS patients with constipation. (2) Methods: A randomized cross-over case-control study was conducted, including patients with IBS and constipation (IBS-C), who were randomized into two groups receiving a specific constipation diet with or without a food supplement containing inulin, choline and silymarin (Stoptoxin®, Fiterman Pharma, Iasi, Romania). Patients were evaluated at baseline, after four and eight weeks, using a questionnaire to assess IBS symptoms. (3) Results: 51 IBS-C patients were included, of which 47 patients finished the trial (33 women, mean age 52.82 years). Adding Stoptoxin® to a diet for constipation brought extra benefits. Abdominal pain severity improved by 68.3% after the diet and Stoptoxin® (p = 0.004) and abdominal bloating severity parameter improved by 34.8% (p = 0.040). The stool number per week and the stool consistency according to the Bristol scale were improved, but without statistical significance between groups (p > 0.05). (4) Conclusions: The combination of inulin, choline and silymarin associated with a specific-constipation diet had obvious clinical beneficial effects on IBS-C patients in terms of bowel movement, abdominal pain and bloating.
(1) 背景：肠易激综合征（IBS）是一种常见疾病，涉及多种病理生理机制。对所有IBS患者采用单一治疗方法是不可能的。益生元可能对便秘型IBS患者有有益作用。(2) 方法：进行了一项随机交叉病例对照研究，纳入便秘型IBS（IBS-C）患者，这些患者被随机分为两组，一组接受特定的便秘饮食，另一组接受含菊粉、胆碱和水飞蓟宾的食物补充剂（Stoptoxin®，Fiterman Pharma，罗马尼亚雅西）。在基线、四周和八周后，使用问卷评估IBS症状对患者进行评估。(3) 结果：纳入51例IBS-C患者，其中47例完成试验（33名女性，平均年龄52.82岁）。在便秘饮食中添加Stoptoxin®带来了额外益处。饮食加Stoptoxin®后腹痛严重程度改善了68.3%（p = 0.004），腹胀严重程度参数改善了34.8%（p = 0.040）。每周排便次数和根据布里斯托量表评估的大便稠度有所改善，但两组间无统计学意义（p > 0.05）。(4) 结论：菊粉、胆碱和水飞蓟宾与特定便秘饮食联合使用，在排便、腹痛和腹胀方面对IBS-C患者有明显的临床有益效果。
