年轻女性乳腺佩吉特病：病例报告及与中老年患者的比较
Mammary Paget's Disease of Young Females: Case Reports and Comparison With Middle-Aged and Elderly Patients.
作者信息
Lv Chun-Yan, Cheng Xian-Kui, Guo Zhong-Yue, Liu Li, Cai Jian, Lei Tao, Tang Yan
机构信息
Basic Medical School, Chengdu University, Chengdu, China.
Department of Pathology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
出版信息
Clin Pathol. 2023 Apr 6;16:2632010X231162700. doi: 10.1177/2632010X231162700. eCollection 2023 Jan-Dec.
PURPOSE
Mammary Paget's disease (PD) in young women has seldom been reported. The aim of this study was to improve the knowledge of the clinicopathological characteristics in young patients with PD to provide a basis for the precise treatment of young patients.
METHODS
The medical records and pathological slides of 8 young patients (younger than 40 years old) with PD were reviewed. The data of 20 patients over 40 years old within the same period were used as controls.
RESULTS
The average age was 32.00 ± 3.96 years for the young patient group, with the youngest aged 27 years. The first symptom, physical examination, Paget cell morphology, and immunohistochemical marks were the same in different age groups. But young patients have varied tumor distribution patterns, fewer interstitial inflammatory cells, and advanced pathological local lymphatic metastasis than older patients in the same period.
CONCLUSIONS
PD in young women has unique histopathological features. These manifestations seem to provide personalized treatment for PD treatment in young patients. More research is needed to clarify the significance of this research.
目的
年轻女性乳腺佩吉特病（PD）鲜有报道。本研究旨在提高对年轻PD患者临床病理特征的认识，为年轻患者的精准治疗提供依据。
方法
回顾了8例年龄小于40岁的年轻PD患者的病历和病理切片。将同期20例40岁以上患者的数据作为对照。
结果
年轻患者组平均年龄为32.00±3.96岁，最小年龄为27岁。不同年龄组的首发症状、体格检查、佩吉特细胞形态和免疫组化标记相同。但与同期老年患者相比，年轻患者的肿瘤分布模式多样，间质炎症细胞较少，病理局部淋巴结转移较晚。
结论
年轻女性的PD具有独特的组织病理学特征。这些表现似乎为年轻患者的PD治疗提供了个性化治疗方案。需要更多研究来阐明本研究的意义。
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